FirstList

The conserved domain familes in this list correspond to those found in the XL file: 0_all_dist_fin_nr.xls. This file has the families sorted in ascending order by number of coevolving positions with residue c, then by number of coevolving positions with residue c, then by descending order by number of residues between the two positions, and finally by descending order by number of sequences in the alignment used to calculate mutual information.

• CamelCaseFamilyName, CDD name, number of sequences in family
• These protein families contain >= 125 sequences, and have at least one pair of residues where both residues coevolve only with one other and the residues are separated by 10 or more others. These families were used in the calculation for number of sequences vs distance.
• CamelCaseFamilyName, CDD name, number of sequences in family
• pfam00400 WD domain G beta repeat 1436
• cd00054 Calcium binding EGF like domain present in a large number 562
• pfam03466 LysR substrate binding domain 434
• pfam00520 Ion transport protein 362
• cd01182 DNA breaking rejoining enzymes intergrase recombinases C terminal catalytic domain 314
• cd00158 Rhodanese Homology Domain RHOD 311
• cd00156 Signal receiver domain 307
• cd00041 CUB domain 294
• cd00038 effector domain of the CAP family of transcription factors 292
• COG1132 ABC type multidrug transport system ATPase and permease components 280
• cd00174 Src homology 3 domains 276
• COG0451 Nucleoside diphosphate sugar epimerases 268
• pfam04542 Sigma 70 region 2 261
• cd00180 Serine Threonine protein kinases catalytic domain 254
• cd00408 Dihydrodipicolinate synthase family 251
• pfam00535 Glycosyl transferase 250
• cd00867 Trans Isoprenyl Diphosphate Synthases Trans_IPPS of class 1 isoprenoid biosynthesis 233
• cd00751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage 222
• cd00093 Helix turn helix XRE family like proteins 204
• COG1024 Enoyl CoA hydratase carnithine racemase 202
• pfam00104 Ligand binding domain of nuclear hormone receptor 184
• cd00084 High Mobility Group HMG box is found in a variety 178
• pfam00270 DEAD DEAH box helicase 178
• cd00090 Arsenical Resistance Operon Repressor and similar prokaryotic metal regulated homodimeric 177
• pfam00027 Cyclic nucleotide binding domain 169
• COG1249 Pyruvate 2 oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase E3 component and 154
• cd00190 Trypsin like serine protease 148
• cd00834 Beta ketoacyl acyl carrier protein ACP synthase KAS type I 144
• cd00166 Sterile alpha motif 142
• COG0251 Putative translation initiation inhibitor yjgF family 141
• pfam00102 Protein tyrosine phosphatase 139
• cd00685 Trans Isoprenyl Diphosphate Synthases Trans_IPPS head to tail HT 1 138
• cd00189 Tetratricopeptide repeat domain 137
• cd01450 Von Willebrand factor type A vWA domain was originally found 132
• COG0366 Glycosidases 127
• pfam00306 ATP synthase alpha beta chain C terminal domain 125