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The conserved domain familes in this list correspond to those found in the XL file: 0_all_dist_fin_nr.xls. This file has the families sorted in ascending order by number of coevolving positions with residue c, then by number of coevolving positions with residue c, then by descending order by number of residues between the two positions, and finally by descending order by number of sequences in the alignment used to calculate mutual in formation.

  • CamelCaseFamilyName, CDD name, number of sequences in family

These protein families contain >= 125 sequences, and have at least one pair of residues where both residues coevolve only with one other and the residues are separated by 10 or more others. These families were used in the calculation for number of sequences vs distance. Structures are shown

  • CamelCaseFamilyName, CDD name, number of sequences in family
  • pfam00400 WD domain G beta repeat 1436
  • cd00054 Calcium binding EGF like domain present in a large number 562
  • pfam03466 LysR substrate binding domain 434
  • pfam00520 Ion transport protein 362
  • cd01182 DNA breaking rejoining enzymes intergrase recombinases C terminal catalytic domain 314
  • cd00158 Rhodanese Homology Domain RHOD 311
  • cd00156 Signal receiver domain 307
  • cd00041 CUB domain 294
  • cd00038 effector domain of the CAP family of transcription factors 292
  • COG1132 ABC type multidrug transport system ATPase and permease components 280
  • cd00174 Src homology 3 domains 276
  • COG0451 Nucleoside diphosphate sugar epimerases 268
  • pfam04542 Sigma 70 region 2 261
  • cd00180 Serine Threonine protein kinases catalytic domain 254
  • cd00408 Dihydrodipicolinate synthase family 251
  • pfam00535 Glycosyl transferase 250
  • cd00867 Trans Isoprenyl Diphosphate Synthases Trans_IPPS of class 1 isoprenoid biosynthesis 233
  • cd00751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage 222
  • cd00093 Helix turn helix XRE family like proteins 204
  • COG1024 Enoyl CoA hydratase carnithine racemase 202
  • pfam00104 Ligand binding domain of nuclear hormone receptor 184
  • cd00084 High Mobility Group HMG box is found in a variety 178
  • pfam00270 DEAD DEAH box helicase 178
  • cd00090 Arsenical Resistance Operon Repressor and similar prokaryotic metal regulated homodimeric 177
  • pfam00027 Cyclic nucleotide binding domain 169
  • COG1249 Pyruvate 2 oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase E3 component and 154
  • cd00190 Trypsin like serine protease 148
  • cd00834 Beta ketoacyl acyl carrier protein ACP synthase KAS type I 144
  • cd00166 Sterile alpha motif 142
  • COG0251 Putative translation initiation inhibitor yjgF family 141
  • pfam00102 Protein tyrosine phosphatase 139
  • cd00685 Trans Isoprenyl Diphosphate Synthases Trans_IPPS head to tail HT 1 138
  • cd00189 Tetratricopeptide repeat domain 137
  • cd01450 Von Willebrand factor type A vWA domain was originally found 132
  • COG0366 Glycosidases 127
  • pfam00306 ATP synthase alpha beta chain C terminal domain 125

These protein families contain < 125 sequences, and have at least one pair of residues where both residues coevolve only with one other and the residues are separated by 10 or more others. These families were used in the calculation for number of sequences vs distance. Structurs are not shown

  • cd00296 SIR2 superfamily of proteins includes silent information regulator 2 Sir2 121
  • cd00203 Zinc dependent metalloprotease 119
  • pfam02769 AIR synthase related protein C terminal domain 117
  • pfam01546 Peptidase family M20 M25 M40 116
  • pfam03992 Antibiotic biosynthesis monooxygenase 116
  • COG0210 Superfamily I DNA and RNA helicases 114
  • COG0329 Dihydrodipicolinate synthase N acetylneuraminate lyase 114
  • pfam00135 Carboxylesterase 113
  • cd00267 ABC ATP binding cassette transporter nucleotide binding domain 107
  • COG0683 ABC type branched chain amino acid transport systems periplasmic component 107
  • pfam00347 Ribosomal protein L6 103
  • pfam00620 RhoGAP domain 101
  • COG0304 3 oxoacyl acyl carrier protein synthase 101
  • cd01568 Quinolinate phosphoribosyl transferase QAPRTase or QPRTase also called nicotinate nucleotide 98
  • cd00374 Ribonuclease T2 RNase T2 is a widespread family of secreted 96
  • pfam00210 Ferritin like domain 96
  • COG0626 Cystathionine beta lyases cystathionine gamma synthases 95
  • cd00757 ThiF_MoeB_HesA 93
  • COG0057 Glyceraldehyde 3 phosphate dehydrogenase erythrose 4 phosphate dehydrogenase 91
  • cd00200 WD40 domain found in a number of eukaryotic proteins that 90
  • pfam01193 RNA polymerase Rpb3 Rpb11 dimerisation domain 90
  • COG0258 5 3 exonuclease including N terminal domain of PolI 89
  • cd01407 SIR2 family of proteins includes silent information regulator 2 Sir2 89
  • cd00433 Cytosol aminopeptidase family catalytic domain 88
  • cd01337 malate dehydrogenases MDH glycosomal and mitochondrial 87
  • COG0468 RecA RadA recombinase 87
  • cd00515 NTPase HAM1 85
  • COG0476 Dinucleotide utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 84
  • cd00868 Terpene cyclases Class 1 C1 of the class 1 family 83
  • cd00950 Dihydrodipicolinate synthase DHDPS is a key enzyme in lysine biosynthesis 82
  • COG0024 Methionine aminopeptidase 81
  • pfam00403 Heavy metal associated domain 79
  • cd00537 Methylenetetrahydrofolate reductase MTHFR 78
  • cd00452 KDPG and KHG aldolase 78
  • pfam00574 Clp protease 77
  • COG2084 3 hydroxyisobutyrate dehydrogenase and related beta hydroxyacid dehydrogenases 76
  • cd00125 Phospholipase A2 76
  • COG0161 Adenosylmethionine 8 amino 7 oxononanoate aminotransferase 75
  • cd00159 GTPase activator protein for Rho like GTPases 75
  • cd01347 TonB dependent Ligand Gated channels are created by a monomeric 75
  • cd01639 IMPase inositol monophosphatase and related domains 75
  • COG0112 Glycine serine hydroxymethyltransferase 75
  • pfam00136 DNA polymerase family B 74
  • COG0605 Superoxide dismutase 74
  • COG0156 7 keto 8 aminopelargonate synthetase and related enzymes 73
  • COG0462 Phosphoribosylpyrophosphate synthetase 73
  • COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes 73
  • COG0050 GTPases translation elongation factors 72
  • cd01555 UDP N acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part 72
  • COG0776 Bacterial nucleoid DNA binding protein 72
  • pfam00450 Serine carboxypeptidase 71
  • cd00684 Plant Terpene Cyclases Class 1 C1 71
  • pfam03936 Terpene synthase family metal binding domain 71
  • COG0088 Ribosomal protein L4 70
  • COG0389 Nucleotidyltransferase DNA polymerase involved in DNA repair 69
  • cd01086 Methionine Aminopeptidase 1 69
  • COG0096 Ribosomal protein S8 69
  • COG0493 NADPH dependent glutamate synthase beta chain and related oxidoreductases 69
  • COG0191 Fructose tagatose bisphosphate aldolase 69
  • COG0532 Translation initiation factor 2 IF 2 68
  • COG0060 Isoleucyl tRNA synthetase 68
  • COG0410 ABC type branched chain amino acid transport systems ATPase component 68
  • pfam03462 PCRF domain 68
  • COG0124 Histidyl tRNA synthetase 67
  • cd01339 LDH like structure and DMH enzymatic activity 66
  • COG1181 D alanine D alanine ligase and related ATP grasp enzymes 65
  • cd00814 This is the catalytic core domain of methionine tRNA synthetase 64
  • COG0441 Threonyl tRNA synthetase 64
  • COG0215 Cysteinyl tRNA synthetase 64
  • cd00831 Chalcone and stilbene synthases 63
  • COG0009 Putative translation factor SUA5 63
  • COG0018 Arginyl tRNA synthetase 61
  • COG0085 DNA directed RNA polymerase beta subunit 140 kD subunit 61
  • cd00193 Soluble NSF N ethylmaleimide sensitive fusion protein Attachment protein SNAP 61
  • COG0208 Ribonucleotide reductase beta subunit 60
  • cd00773 Class II Histidinyl tRNA synthetase HisRS like catalytic core domain 59
  • COG0015 Adenylosuccinate lyase 58
  • pfam01168 Alanine racemase N terminal domain 58
  • COG0424 Nucleotide binding protein implicated in inhibition of septum formation 57
  • COG0347 Nitrogen regulatory protein PII 57
  • COG0766 UDP N acetylglucosamine enolpyruvyl transferase 56
  • cd00008 5 3 exonuclease 56
  • COG0519 GMP synthase PP ATPase domain subunit 56
  • COG0022 Pyruvate 2 oxoglutarate dehydrogenase complex dehydrogenase E1 component eukaryotic type 55
  • COG0202 DNA directed RNA polymerase alpha subunit 40 kD subunit 55
  • COG2723 Beta glucosidase 6 phospho beta glucosidase beta galactosidase 55
  • COG0108 3 4 dihydroxy 2 butanone 4 phosphate synthase 55
  • cd00260 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic 55
  • COG0128 5 enolpyruvylshikimate 3 phosphate synthase 54
  • cd00806 Tryptophanyl tRNA synthetase TrpRS catalytic core domain 54
  • pfam00181 Ribosomal Proteins L2 RNA binding domain 54
  • cd01377 Myosin motor domain type II myosins 52
  • COG0707 UDP N acetylglucosamine LPS N acetylglucosamine transferase 52
  • cd00042 Cystatin like domain 52
  • COG0592 DNA polymerase sliding clamp subunit PCNA homolog 51
  • COG0174 Glutamine synthetase 50
  • cd01441 Histidine ammonia lyase HAL catalyzes the first step in the 50
  • COG0151 Phosphoribosylamine glycine ligase 50
  • COG0021 Transketolase 50
  • cd00179 Syntaxin N terminus domain 50
  • pfam00586 AIR synthase related protein N terminal domain 50
  • COG0045 Succinyl CoA synthetase beta subunit 48
  • pfam01709 Domain of unknown function DUF28 48
  • cd00805 Tyrosinyl tRNA synthetase TyrRS catalytic core domain 48
  • COG0411 ABC type branched chain amino acid transport systems ATPase component 48
  • COG0133 Tryptophan synthase beta chain 47
  • pfam01409 tRNA synthetases class II core domain F 47
  • COG1159 GTPase 47
  • pfam00478 IMP dehydrogenase GMP reductase domain 47
  • cd00078 HECT domain 47
  • COG0141 Histidinol dehydrogenase 46
  • cd01298 TRZ ATZ family contains enzymes from the atrazine degradation pathway 46
  • pfam00082 Subtilase family 45
  • cd01336 malate dehydrogenases MDH cytoplasmic and cytosolic 45
  • COG0630 Type IV secretory pathway VirB11 components and related ATPases involved 45
  • pfam01347 Lipoprotein amino terminal region 43
  • COG0147 Anthranilate para aminobenzoate synthases component I 43
  • COG1304 L lactate dehydrogenase FMN dependent and related alpha hydroxy acid 43
  • cd00449 PyridoxaL 5 Phosphate Dependent Enzymes class IV PLPDE_IV 43
  • cd00496 Phenylalanyl tRNA synthetase PheRS alpha chain catalytic core domain 43
  • COG0149 Triosephosphate isomerase 43
  • pfam00580 UvrD REP helicase 43
  • COG0284 Orotidine 5 phosphate decarboxylase 43
  • COG0843 Heme copper type cytochrome quinol oxidases subunit 1 42
  • COG1004 Predicted UDP glucose 6 dehydrogenase 42
  • cd00770 Seryl tRNA synthetase SerRS class II core catalytic domain 42
  • COG0207 Thymidylate synthase 42
  • COG4886 Leucine rich repeat LRR protein 42
  • pfam00685 Sulfotransferase domain 41
  • COG0669 Phosphopantetheine adenylyltransferase 41
  • cd01054 Aromatic and Alkene Monooxygenase Hydroxylases alpha and beta subunits AAMH_AB 41
  • COG0276 Protoheme ferro lyase ferrochelatase 41
  • COG0041 Phosphoribosylcarboxyaminoimidazole NCAIR mutase 41
  • cd01276 Protein Kinase C Interacting protein related PKCI PKCI and related 41
  • pfam02932 Neurotransmitter gated ion channel transmembrane region 41
  • pfam01588 Putative tRNA binding domain 41
  • cd00498 Heat shock protein 33 Hsp33 Cytosolic protein that acts as 41
  • COG1200 RecG like helicase 40
  • pfam00118 TCP 1 cpn60 chaperonin family 40
  • COG0104 Adenylosuccinate synthase 39
  • cd00124 Myosin motor domain 39
  • cd00019 AP endonuclease family 2 39
  • COG0623 Enoyl 39
  • pfam01433 Peptidase family M1 39
  • COG2255 Holliday junction resolvasome helicase subunit 39
  • COG0580 Glycerol uptake facilitator and related permeases Major Intrinsic Protein Family 39
  • COG0496 Predicted acid phosphatase 38
  • COG0299 Folate dependent phosphoribosylglycinamide formyltransferase PurN 38
  • pfam02629 CoA binding domain 38
  • cd00956 Transaldolase like fructose 6 phosphate aldolases FSA found in bacteria 38
  • COG1209 dTDP glucose pyrophosphorylase 37
  • cd00818 This is the catalytic core domain of isoleucine amino acyl 37
  • COG1544 Ribosome associated protein Y PSrp 1 37
  • cd00774 Glycyl tRNA synthetase GlyRS like class II core catalytic domain 37
  • COG0150 Phosphoribosylaminoimidazole AIR synthetase 37
  • COG0722 3 deoxy D arabino heptulosonate 7 phosphate DAHP synthase 36
  • cd00778 Prolyl tRNA synthetase ProRS class II core catalytic domain 36
  • cd00776 Asx tRNA synthetase AspRS AsnRS class II core domain 36
  • COG0648 Endonuclease IV 36
  • COG0162 Tyrosyl tRNA synthetase 36
  • COG0123 Deacetylases including yeast histone deacetylase and acetoin utilization protein 35
  • cd00667 Ring hydroxylating dioxygenase beta subunit 35
  • COG0260 Leucyl aminopeptidase 35
  • cd00817 This is the catalytic core domain of valine amino acyl 35
  • COG0176 Transaldolase 34
  • COG0373 Glutamyl tRNA reductase 34
  • cd00171 Sec7 domain 34
  • COG1076 DnaJ domain containing proteins 1 34
  • COG1290 Cytochrome b subunit of the bc complex 34
  • pfam00275 EPSP synthase 3 phosphoshikimate 1 carboxyvinyltransferase 34
  • pfam01602 Adaptin N terminal region 33
  • COG1053 Succinate dehydrogenase fumarate reductase flavoprotein subunit 33
  • COG0005 Purine nucleoside phosphorylase 33
  • pfam01095 Pectinesterase 33
  • pfam00970 Oxidoreductase FAD binding domain 33
  • COG0120 Ribose 5 phosphate isomerase 33
  • COG0371 Glycerol dehydrogenase and related enzymes 32
  • cd00807 Glutaminyl tRNA synthetase GlnRS and non descriminating Glutamyl tRNA synthetase 31
  • COG0058 Glucan phosphorylase 31
  • pfam01118 Semialdehyde dehydrogenase NAD binding domain 31
  • COG1448 Aspartate tyrosine aromatic aminotransferase 31
  • COG0538 Isocitrate dehydrogenases 30
  • cd00795 Nitric oxide synthase NOS eukaryotic oxygenase domain 30
  • cd01412 SIRT5_Af1_CobB Eukaryotic archaeal and prokaryotic group class3 which includes human 30
  • cd00325 Glycoside hydrolase family 19 chitinase domain 30
  • pfam03063 Prismane CO dehydrogenase family 29
  • cd01314 D hydantoinases D HYD also called dihydropyrimidases DHPase and related 29
  • pfam06723 MreB Mbl protein 29
  • cd01378 Myosin motor domain type I myosins 29
  • COG0461 Orotate phosphoribosyltransferase 29
  • cd01437 Poly ADP ribose polymerase parp catalytic domain catalyses the covalent 29
  • pfam03610 PTS system fructose IIA component 29
  • COG0234 Co chaperonin GroES HSP10 29
  • cd00016 Alkaline phosphatase homologues 28
  • COG1207 N acetylglucosamine 1 phosphate uridyltransferase contains nucleotidyltransferase and I patch 28
  • pfam01053 Cys Met metabolism PLP dependent enzyme 28
  • COG0363 6 phosphogluconolactonase Glucosamine 6 phosphate isomerase deaminase 28
  • COG1490 D Tyr tRNAtyr deacylase 28
  • COG1087 UDP glucose 4 epimerase 28
  • pfam00993 Class II histocompatibility antigen alpha domain 28
  • COG0289 Dihydrodipicolinate reductase 27
  • cd01557 BCAT_beta_family Branched chain aminotransferase catalyses the transamination of the branched 27
  • pfam00696 Amino acid kinase family 27
  • COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme glutaminyl transferase 26
  • cd00286 Tubulin FtsZ Family includes tubulin alpha beta and gamma chains 26
  • cd00187 DNA Topoisomerase subtype IIA 25
  • pfam00291 Pyridoxal phosphate dependent enzyme 25
  • COG0269 3 hexulose 6 phosphate synthase and related proteins 25
  • pfam00521 DNA gyrase topoisomerase IV subunit A 24
  • COG1220 ATP dependent protease HslVU ClpYQ ATPase subunit 24
  • pfam00680 RNA dependent RNA polymerase 24
  • cd00119 C type lysozyme 1 4 beta N acetylmuramidase LYZ and 24
  • COG2109 ATP corrinoid adenosyltransferase 24
  • pfam00294 pfkB family carbohydrate kinase 23
  • pfam00884 Sulfatase 22
  • cd01132 F1 ATP synthase alpha central domain 22
  • cd00948 Fructose 1 6 bisphosphate aldolase 22
  • pfam00861 Ribosomal L18p L5e family 22
  • pfam00248 Aldo keto reductase family 22
  • COG2038 NaMN DMB phosphoribosyltransferase 21
  • cd00365 Hydroxymethylglutaryl coenzyme A HMG CoA reductase HMGR is a tightly 21
  • pfam00436 Single strand binding protein family 21
  • COG1043 Acyl 20
  • pfam00071 Ras family 20
  • pfam00448 SRP54 type protein GTPase domain 20
  • COG0812 UDP N acetylmuramate dehydrogenase 19
  • COG0779 Uncharacterized protein conserved in bacteria 19
  • COG0118 Glutamine amidotransferase 17
  • COG0753 Catalase 16
  • COG0113 Delta aminolevulinic acid dehydratase 15
  • cd01421 Inosine monophosphate cyclohydrolase domain 15
  • COG0114 Fumarase 14
  • cd00046 DEAD like helicases superfamily 14
  • cd01012 YcaC related amidohydrolases 13
  • pfam00793 DAHP synthetase I family 11
  • pfam01039 Carboxyl transferase domain 10
  • pfam00390 Malic enzyme N terminal domain 10
  • pfam00141 Peroxidase 9
  • pfam02800 Glyceraldehyde 3 phosphate dehydrogenase C terminal domain 8

These contain >= 125 sequences in which coevolving single residues are separated by less than 10 residues, or where no single coevolving residue pairs are found. These families were not used in the calculation for number of sequences vs distance. Structures are shown

  • pfam00571 CBS domain 923
  • COG0583 Transcriptional regulator 832
  • cd00082 His Kinase A dimerization phosphoacceptor domain 572
  • cd00383 Effector domain of response regulator 519
  • pfam00271 Helicase conserved C terminal domain 497
  • cd00657 Ferritin like diiron carboxylate proteins participate in a range of 485
  • pfam01590 GAF domain 453
  • COG2207 AraC type DNA binding domain containing proteins 420
  • pfam00501 AMP binding enzyme 410
  • cd00636 Helical backbone metal receptor TroA like domain 365
  • pfam00486 Transcriptional regulatory protein C terminal 364
  • cd00385 Isoprenoid Biosynthesis enzymes Class 1 324
  • cd00086 Homeodomain 316
  • pfam00753 Metallo beta lactamase superfamily 314
  • cd00300 L lactate dehydrogenases LDH 271
  • COG1609 Transcriptional regulators 262
  • COG0346 Lactoylglutathione lyase and related lyases 243
  • pfam00004 ATPase family associated with various cellular activities AAA 241
  • cd00043 Cyclin box fold 240
  • cd00254 Lytic Transglycosylase LT and Goose Egg White Lysozyme GEWL domain 226
  • pfam02518 Histidine kinase DNA gyrase B and HSP90 like ATPase 216
  • cd00431 Cysteine hydrolases 203
  • cd00352 Glutamine amidotransferases class II GATase 200
  • cd00342 Porins form aqueous channels for the diffusion of small hydrophillic 191
  • COG0436 Aspartate tyrosine aromatic aminotransferase 189
  • COG0524 Sugar kinases ribokinase family 186
  • cd00516 Phosphoribosyltransferase PRTase type II 185
  • cd00985 Maf_Ham1 180
  • pfam00078 Reverse transcriptase RNA dependent DNA polymerase 176
  • pfam00227 Proteasome A type and B type 173
  • cd00031 Cadherin repeat domain 168
  • pfam00109 Beta ketoacyl synthase N terminal domain 164
  • pfam04545 Sigma 70 region 4 164
  • cd00531 Nuclear transport factor 2 NTF2 like superfamily 162
  • pfam00046 Homeobox domain 160
  • pfam02801 Beta ketoacyl synthase C terminal domain 148
  • pfam00679 Elongation factor G C terminus 148
  • pfam00441 Acyl CoA dehydrogenase C terminal domain 146
  • COG1109 Phosphomannomutase 142
  • pfam01243 Pyridoxamine 5 phosphate oxidase 140
  • cd00056 endonuclease III 140
  • COG0589 Universal stress protein UspA and related nucleotide binding proteins 137
  • pfam01453 D mannose binding lectin 136
  • cd00143 Serine threonine phosphatases family 2C catalytic domain 136
  • cd00830 Ketoacyl acyl carrier protein synthase III KASIII initiates the elongation 130
  • COG0604 NADPH quinone reductase and related Zn dependent oxidoreductases 130
  • cd00079 Helicase superfamily c terminal domain 130
  • COG2141 Coenzyme F420 dependent N5 N10 methylene tetrahydromethanopterin reductase and related 121
  • pfam00091 Tubulin FtsZ family GTPase domain 121
  • COG0459 Chaperonin GroEL HSP60 family 120
  • cd00704 malate dehydrogenases MDH 119
  • COG2771 DNA binding HTH domain containing proteins 118
  • COG1762 Phosphotransferase system mannitol fructose specific IIA domain Ntr type 117
  • cd00945 Class I aldolases 117
  • COG0388 Predicted amidohydrolase 114
  • pfam00702 haloacid dehalogenase like hydrolase 114
  • pfam01565 FAD binding domain 111
  • pfam01522 Polysaccharide deacetylase 110
  • cd00430 Alanine racemase 110
  • cd00211 PTS_IIA PTS system fructose mannitol specific IIA subunit 109
  • pfam01336 OB fold nucleic acid binding domain 108
  • COG1226 Kef type K+ transport systems predicted NAD binding component 107
  • COG0470 ATPase involved in DNA replication 104
  • cd01556 EPSP synthase domain 103
  • pfam06470 SMC proteins Flexible Hinge Domain 102
  • COG1335 Amidases related to nicotinamidase 101
  • pfam00801 PKD domain 100
  • cd01066 A family including aminopeptidase P aminopeptidase M and prolidase 98
  • cd00170 Sec14p like lipid binding domain 98
  • pfam02403 Seryl tRNA synthetase N terminal domain 96
  • pfam00215 Orotidine 5 phosphate decarboxylase HUMPS family 93
  • cd00555 Nucleotide binding protein Maf 93
  • pfam00188 SCP like extracellular protein 92
  • COG0652 Peptidyl prolyl cis trans isomerase rotamase cyclophilin family 91
  • pfam05739 SNARE domain 91
  • COG0520 Selenocysteine lyase 86
  • cd00827 initiating condensing enzymes are a subclass of decarboxylating condensing enzymes 84
  • cd01310 TatD like proteins 84
  • cd01285 Nucleoside deaminases include adenosine guanine and cytosine deaminases 84
  • cd00071 Guanylate kinase homologues 84
  • cd00314 Plant peroxidase superfamily 83
  • cd01572 Quinolinate phosphoribosyl transferase QAPRTase or QPRTase also called nicotinate nucleotide 82
  • pfam00107 Zinc binding dehydrogenase 81
  • COG0518 GMP synthase Glutamine amidotransferase domain 80
  • pfam00216 Bacterial DNA binding protein 79
  • pfam00198 2 oxoacid dehydrogenases acyltransferase catalytic domain 78
  • pfam00656 Caspase domain 78
  • cd00904 Ferritins are the primary iron storage proteins of most living 76
  • cd01061 Ribonuclease T2 RNase T2 is a widespread family of secreted 74
  • COG0206 Cell division GTPase 74
  • pfam00179 Ubiquitin conjugating enzyme 73
  • pfam00664 ABC transporter transmembrane region 72
  • COG0425 Predicted redox protein regulator of disulfide bond formation 71
  • COG0177 Predicted EndoIII related endonuclease 70
  • cd00145 DNA polymerase type B family 70
  • cd00195 Ubiquitin conjugating enzyme E2 catalytic UBCc domain 69
  • COG0115 Branched chain amino acid aminotransferase 4 amino 4 deoxychorismate lyase 69
  • COG0550 Topoisomerase IA 69
  • cd01393 RecA is a bacterial enzyme which has roles in homologous 69
  • pfam01177 Asp Glu Hydantoin racemase 68
  • COG0039 Malate lactate dehydrogenases 68
  • pfam01501 Glycosyl transferase family 8 67
  • cd00635 PLP dependent enzymes class III PLPDE_III 66
  • cd00947 Tagatose 1 6 bisphosphate TBP aldolase and related Type B 65
  • COG0708 Exonuclease III 65
  • COG0294 Dihydropteroate synthase and related enzymes 64
  • COG0503 Adenine guanine phosphoribosyltransferases and related PRPP binding proteins 64
  • COG0303 Molybdopterin biosynthesis enzyme 63
  • COG0167 Dihydroorotate dehydrogenase 63
  • COG0560 Phosphoserine phosphatase 63
  • cd01283 Cytidine deaminase zinc binding domain 62
  • COG0332 3 oxoacyl 61
  • cd00002 protein family related to YbaK Protein From H 61
  • cd00186 DNA Topoisomerase subtype IA 61
  • cd00354 Fructose 1 6 bisphosphatase an enzyme that catalyzes the hydrolysis 60
  • cd00073 linker histone 1 and histone 5 domains 58
  • COG0127 Xanthosine triphosphate pyrophosphatase 58
  • COG0343 Queuine archaeosine tRNA ribosyltransferase 58
  • COG0217 Uncharacterized conserved protein 57
  • pfam01985 CRS1 YhbY domain 57
  • COG0782 Transcription elongation factor 57
  • pfam01783 Ribosomal L32p protein family 57
  • pfam06071 Protein of unknown function DUF933 56
  • pfam01000 RNA polymerase Rpb3 RpoA insert domain 56
  • pfam00445 Ribonuclease T2 family 55
  • COG0125 Thymidylate kinase 55
  • COG0548 Acetylglutamate kinase 55
  • pfam00112 Papain family cysteine protease 54
  • COG1171 Threonine dehydratase 53
  • COG0334 Glutamate dehydrogenase leucine dehydrogenase 53
  • COG0794 Predicted sugar phosphate isomerase involved in capsule formation 51
  • cd01448 Thiosulfate sulfurtransferase TST N terminal inactive domain 51
  • pfam00067 Cytochrome P450 51
  • COG0233 Ribosome recycling factor 50
  • pfam01419 Jacalin like lectin domain 49
  • pfam00117 Glutamine amidotransferase class I 49
  • COG0173 Aspartyl tRNA synthetase 49
  • COG1622 Heme copper type cytochrome quinol oxidases subunit 2 49
  • pfam03099 Biotin lipoate A B protein ligase family 49
  • pfam02900 Catalytic LigB subunit of aromatic ring opening dioxygenase 48
  • pfam00389 D isomer specific 2 hydroxyacid dehydrogenase catalytic domain 48
  • cd01087 Prolidase 47
  • cd00077 Metal dependent phosphohydrolases with conserved HD motif 47
  • COG0540 Aspartate carbamoyltransferase catalytic chain 47
  • COG0781 Transcription termination factor 46
  • COG0473 Isocitrate isopropylmalate dehydrogenase 46
  • COG0038 Chloride channel protein EriC 46
  • pfam05222 Alanine dehydrogenase PNT N terminal domain 45
  • cd00672 This is the catalytic core domain of cysteinyl tRNA synthetase 44
  • COG0333 Ribosomal protein L32 44
  • pfam00579 tRNA synthetases class I W and Y 44
  • cd00232 Heme oxygenase catalyzes the rate limiting step in the degradation 42
  • pfam02441 Flavoprotein 42
  • cd01123 Rad51_DMC1_radA B 42
  • cd00808 Descriminating Glutamyl tRNA synthetase GluRS catalytic core domain 41
  • COG0563 Adenylate kinase and related kinases 41
  • cd00771 Threonyl tRNA synthetase ThrRS class II core catalytic domain 40
  • cd01056 Eukaryotic Ferritin Euk_Ferritin domain 39
  • pfam04014 SpoVT AbrB like domain 39
  • pfam04897 Glutamate synthase amidotransferase domain 39
  • cd00075 Histidine kinase like ATPases 39
  • COG0505 Carbamoylphosphate synthase small subunit 37
  • pfam03960 ArsC family 37
  • cd00958 Class I fructose 1 6 bisphosphate FBP aldolases of the 35
  • cd01293 Bacterial cytosine deaminase and related metal dependent hydrolases 34
  • pfam00481 Protein phosphatase 2C 34
  • cd00575 Nitric oxide synthase NOS produces nitric oxide NO by catalyzing 33
  • cd00481 Ribosomal protein L19e 33
  • pfam01656 Cobyrinic acid a c diamide synthase 33
  • COG2201 Chemotaxis response regulator containing a CheY like receiver domain and 33
  • pfam05192 MutS domain III 33
  • cd00853 NifX belongs to a family of iron molybdenum cluster binding 32
  • cd00292 Elongation factor 1 beta EF1B guanine nucleotide exchange domain 31
  • COG1788 Acyl CoA acetate 3 ketoacid CoA transferase alpha subunit 31
  • COG0756 dUTPase 31
  • COG0421 Spermidine synthase 31
  • pfam01042 Endoribonuclease L PSP 29
  • cd01011 Nicotinamidase pyrazinamidase PZase 29
  • COG0823 Periplasmic component of the Tol biopolymer transport system 29
  • cd00115 Low molecular weight phosphatase family 28
  • pfam00890 FAD binding domain 26
  • COG2818 3 methyladenine DNA glycosylase 24
  • pfam00994 Probable molybdopterin binding domain 24
  • COG0638 20S proteasome alpha and beta subunits 24
  • cd00476 SAICAR synthetase catalyzes the seventh step of the de novo 23
  • pfam01432 Peptidase family M3 18
  • pfam00831 Ribosomal L29 protein 18
  • pfam00394 Multicopper oxidase 15
  • cd00269 DEXH box helicases 13