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- These contain > 125 sequences in which coevolving single residues are separated by less than 10 residues, or where no single coevolving residue pairs are found. These families were not used in the calculation for number of sequences vs distance.
- pfam00571 CBS domain 923
- COG0583 Transcriptional regulator 832
- cd00082 His Kinase A dimerization phosphoacceptor domain 572
- cd00383 Effector domain of response regulator 519
- pfam00271 Helicase conserved C terminal domain 497
- cd00657 Ferritin like diiron carboxylate proteins participate in a range of 485
- pfam01590 GAF domain 453
- COG2207 AraC type DNA binding domain containing proteins 420
- pfam00501 AMP binding enzyme 410
- cd00636 Helical backbone metal receptor TroA like domain 365
- pfam00486 Transcriptional regulatory protein C terminal 364
- cd00385 Isoprenoid Biosynthesis enzymes Class 1 324
- cd00086 Homeodomain 316
- pfam00753 Metallo beta lactamase superfamily 314
- cd00300 L lactate dehydrogenases LDH 271
- COG1609 Transcriptional regulators 262
- COG0346 Lactoylglutathione lyase and related lyases 243
- pfam00004 ATPase family associated with various cellular activities AAA 241
- cd00043 Cyclin box fold 240
- cd00254 Lytic Transglycosylase LT and Goose Egg White Lysozyme GEWL domain 226
- pfam02518 Histidine kinase DNA gyrase B and HSP90 like ATPase 216
- cd00431 Cysteine hydrolases 203
- cd00352 Glutamine amidotransferases class II GATase 200
- cd00342 Porins form aqueous channels for the diffusion of small hydrophillic 191
- COG0436 Aspartate tyrosine aromatic aminotransferase 189
- COG0524 Sugar kinases ribokinase family 186
- cd00516 Phosphoribosyltransferase PRTase type II 185
- cd00985 Maf_Ham1 180
- pfam00078 Reverse transcriptase RNA dependent DNA polymerase 176
- pfam00227 Proteasome A type and B type 173
- cd00031 Cadherin repeat domain 168
- pfam00109 Beta ketoacyl synthase N terminal domain 164
- pfam04545 Sigma 70 region 4 164
- cd00531 Nuclear transport factor 2 NTF2 like superfamily 162
- pfam00046 Homeobox domain 160
- pfam02801 Beta ketoacyl synthase C terminal domain 148
- pfam00679 Elongation factor G C terminus 148
- pfam00441 Acyl CoA dehydrogenase C terminal domain 146
- COG1109 Phosphomannomutase 142
- pfam01243 Pyridoxamine 5 phosphate oxidase 140
- cd00056 endonuclease III 140
- COG0589 Universal stress protein UspA and related nucleotide binding proteins 137
- pfam01453 D mannose binding lectin 136
- cd00143 Serine threonine phosphatases family 2C catalytic domain 136
- cd00830 Ketoacyl acyl carrier protein synthase III KASIII initiates the elongation 130
- COG0604 NADPH quinone reductase and related Zn dependent oxidoreductases 130
- cd00079 Helicase superfamily c terminal domain 130
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