Dr. Alan Dennis
BSc, MSc (S. Africa); PhD, MBA, Toronto
Associate Professor
Division of Clinical Biochemistry
Dept. of Biochemistry
Clinical Biochemist
London Health Sciences Centre
519-685-8500 x77626
alan.dennis@lhsc.on.ca
Clinical Diagnostic Testing for Cancer and Pregnancy

In our clinical research, we use patients' specimens to improve diagnostic testing for cancer. Chromagranin A is secreted by tumours of neuroendocrine origin. We compare different methods of detecting chromagranin A in a co-hort of patients with these tumours. Our methods differ with regard to sensitivity to the whole molecule of chromagranin A or to the whole molecule plus its breakdown products.
The second aspect of our research involves seeking methods to quality control an ultrasound measurement made in the 10-13th week of pregnancy. By using this measurement as a laboratory test, a Down syndrome risk calculation can be made.
Updated by L. Weir, Apr 2010.


