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Our
research interests include .....
Biological
Mass Spectrometry and Proteomics
We are using modern mass spectrometry techniques based on
both MALDI or electrospray ionization to characterize a wide
range of biomolecules as
well as their complexes.
 Details
of projects
Antimicrobial
Peptides
Histatins are a class of antimicrobial
peptides found in the
saliva of
man and of other primates. We are studying their
conformational
properties by various biophysical techniques
in order to gain insight
in their mode of action.
Details
of projects
Inhibitors Proteins of Serine Proteases
We are studying a small inibitory protein eglin c,
isolated
from the
leech Hirudo medicinalis. The goal is to develop
highly selective and non-immunogenic proteins as inhibitors
of physiologically relevant
proteases.
Details
of projects
Amino Acids Chemistry
We have recently discovered a general method
for the
synthesis of
optically active alpha-amino acids. We have
used this approach to
prepare amino acid analogs as selective
receptor agonists for the
glutamate receptors or as enzyme
inhibitors for important enzymes.
Details
of projects
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Welcome
to the Lajoie Lab
