1 Buscemi, N., Murray, C., Doherty-Kirby, A.., Lajoie, G., Sussman, M. A. and Van Eyk, J. E. (2005) Myocardial subproteomic analysis of a constitutively active Rac1 expressing transgenic mouse with lethal myocardical hypertrophy Am. J. Physiol. Heart 289:2325-2333.
2 Zhang, H., Zhang, C., Lajoie, G., and Yeung, K. K-C. (2005) Selective sampling of phosphopeptides for detection by MALDI mass spectrometry Anal. Chem. 77(18):6078-6084.
3 Liu, S., Zhang, C., Campbell, J. L., Zhang, H., Yeung, K. K-C., Han, V. K. M., and Lajoie, G. (2005) Formation of phosphopeptide-metal ion complexes in liquid chromatography/electrospray mass spectrometry and their influence on phosphopeptide detection. Rapid Commun. Mass Spectrom. 19(19):2747–2756 . 4 Reinking, J., Lam, M. M., Pardee, K., Sampson, H. M., Liu, S., Yang, P., Williams, S., White, W., Lajoie, G., Edwards, A., and Krause, H. M. (2005) The Drosophila nuclear receptor e75 contains heme and is gas responsive. Cell. 122(2):195-207. 5 Keykhosravani, K., Doherty-Kirby, A., Zhang, C., Goldberg, H. A., Hunter, G. K., and Lajoie, G. (2005) Comprehensive identification of posttranslational modifications in rat bone osteopontin by mass spectrometry. Biochemistry 44(18):6990-7003.
6 Kim, A. R., Doherty-Kirby, A., Lajoie, G., Rylett, R. J., and Shilton, B. H. Two methods for large-scale purification of recombinant human choline acetyltransferase. Protein Expr. Purif. 2005 Mar;40(1):107-17. 7 Canton, D. A., Olsten, M. K., Kim, K., Doherty-Kirby, A., Lajoie, G., Cooper, J. A. and Litchfield, D. W. (2005) The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein. Mol. Cell. Biol. 25(9):3519-34.
8 Perdicakis, B., Montgomery, H. J., Abbott, G. L., Fishlock, D., Lajoie, G. A., Guillemette, J. G., and Jervis, E. (2005). Photocontrol of nitric oxide production in cell culture using a caged isoform selective inhibitor. Bioorg. Med. Chem. 13(1):47-57. 9 Simmons, D. A., Wilson, D. J., Lajoie, G. A., Doherty-Kirby, A., and Konermann, L. (2004) Subunit disassembly and unfolding of hemoglobin studied by time-resolved electrospray mass spectrometry. Biochemistry 43(46):14792-14801. 10 Dobransky, T., Doherty-Kirby, A., Kim, A. R.., Brewer, D., Lajoie, G., and Rylett, R. J. (2004) Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity. J. Biol. Chem. 279(50):52059-52068.
11 Dempsey, B. R., Wrona, M., Moulin, J. M., Gloor, G. B., Jalilehvand, F., Lajoie, G., Shaw, G. S., and Shilton, B. H. (2004) Solution NMR structure and X-ray absorption analysis of the C-terminal zinc-binding domain of the SecA ATPase. Biochemistry 43(29):9361-9371. 12 Pampena, D. A., Robertson, K. A., Litvinova, O., Lajoie, G., Goldberg, H. A. and Hunter, G. K. (2004) Inhibition of hydroxyapatite formation by osteopontin phosphopeptides. Biochem. J. 378(Pt 3):1083-1087. 13 Zhang, C., Doherty-Kirby, A., van Huystee, R., and Lajoie, G. (2004) Investigation of cationic peanut peroxidase glycans by electrospray ionization mass spectrometry. Phytochemistry 65(11):1575-1588. 14 Dale, S. E., Doherty-Kirby, A., Lajoie, G., and Heinrichs, D. E. (2004) Role of siderophore biosynthesis in the virulence of Staphylococcus aureus: identification and characterization of genes involved in the production of a siderophore. Infect. Immun. 72(1)29-37. 15 Ma, B., Zhang, K., Hendrie, C., Liang, C., Li, M., Doherty-Kirby, A., and Lajoie, G. (2003) PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry. Rapid Commun. Mass Spectrom.17(20):2337-2342. 16 Buscemi, N., Doherty-Kirby, A., Sussman, M. A., Lajoie, G., Van Eyk J. E. (2003) Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance. Mol. Cell. Biochem. 251(1-2):145-151. 17 Sanishvili, R., Yakunin, A. F., Laskowski, R. A., Skarina, T., Evodokimova, E., Doherty-Kirby, A., Lajoie, G. A., Thornton, J. M., Arrowsmith, C. H., Savchenko, A., Joachimiak, A., and Edwards, A.M. (2003) Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli. J. Biol. Chem. 278(28):26039-26045. 18 Donella-Deana, A., Cesaro, L., Sarno, S., Ruzzene, M., Brunati, A. M., Marin, O., Vilk, G., Doherty-Kirby, A., Lajoie, G., Litchfield, D. W., and Pinna, L. A. (2003) Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochem. J. 372(Pt 3):841-849. 19 Dobransky, T., Brewer, D., Lajoie, G. A., and Rylett, R. J. (2003) Phosphorylation of 69 kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42. J. Biol. Chem. 278(8), 5883-5893 . 20 Fishlock, D., Perdicakis, B., Montgomery, H. J., Guillemette, J. G., Jervis, E., and Lajoie, G. A. (2003) Synthesis and evaluation of trans 3,4-cyclopropyl L-arginine analogues as isoform selective inhibitors of nitric oxide synthase. Bioorg. Med. Chem. 11(6):869-873.
21 Graham, L. A., Brewer, D., Lajoie, G., and Davies, P. L. (2003) Characterization of a subfamily of Beetle Odorant-binding Proteins Found in Hemolymph. Mol. .Cell. Proteomics 2(8):541-549.
22 Siemann S., Brewer D., Clarke A. J., Dmitrienko, G., Lajoie, G., and Viswanatha, T. (2002) IMP-1 metallo-beta-lactamase: effect of chelators and assessment of metal requirement by electrospray mass spectrometry. Biochim Biophys Acta. 1571(3):190-200. 23 Brewer D. and Lajoie G. (2002) Structure-based design of potent histatin analogues. Biochemistry. 41(17):5526-36. 24 Montgomery, H. J., Perdicakis, B., Fishlock, D., Lajoie, G. A., Jervis, E., and Guillemette J. G. (2002) Photo-control of nitric oxide synthase activity using a caged isoform specific inhibitor. Bioorg Med Chem. 10(6):1919-1927. 25 Fishlock, D., Guillemette, J. G., and Lajoie G. A. (2002) Synthesis of syn and anti isomers of trans-cyclopropyl arginine. J. Org. Chem. 67(7):2352-2354. 26 Doherty-Kirby A. L. and Lajoie G. A. (2002) Investigation of calcium-binding proteins using electrospray ionization mass spectrometry. Methods Mol Biol. 173:161-74. 27 Rose, N. G. W., Luo, Y., Evindar, G., Blaskovich, M., Wilkinson, S. and Lajoie, G. A. (2001) Preparation of 1-[N-benzyloxycarbonyl-(1S)-1-amino-2-oxoethyl]-4-methyl-2,6,7-trioxabicyclo-[2.2.2.] ortho (OBO) ester. Organic Syntheses 79:216-227.
28 Luo, Y., Evindar, G., Fishlock, D., and Lajoie, G. A. (2001) Synthesis of N-protected N-methyl amino acids. Tetrahedron Lett. 42(23):3807-3809.
29 Rose, N. G. W., Blaskovich, M. A., Wong, A. and Lajoie, G. (2001) Synthesis of enantiomerically enriched b-g-didehydro amino acids. Tetrahedron 57(8):1497-1507. 30 Yeh, S., Moffatt, B. A., Griffith, M., Xiong, F., Yang, D. S., Wiseman, S. B., Sarhan, F., Danyluk, J., Xue, Y. Q., Hew, C. L., Doherty-Kirby ,A., and Lajoie, G. (2000) Chitinase genes responsive to cold encode antifreeze proteins in winter cereals. Plant Physiol. 124(3):1251-1264. 31 Brewer, D., and Lajoie, G. (2000) Evaluation of the metal binding properties of the histidine-rich antimicrobial peptides histatin 3 and 5 by electrospray ionization mass spectrometry. Rapid Commun. Mass. Spectrom. 14(19):1736-1745.
Book Chapters
1 Doherty-Kirby, A. and Lajoie, G. (2000) Side-chain protecting groups. Solid-Phase Synthesis - A Practical Guide (Kates, S. A. and Albericio, F., Eds.) p. 129-195, Marcel Dekker, New York.
1 S. C. Bendall, A. Rouleau, L. Gallacher, D. George, M. Bhatia, and G. Lajoie. Profile of secreted proteins in conditioned media which supports the prolonged growth of human embryonic stem cells (hESC). 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 2 J. L Campbell, C. Zhang, W. Yang, B. Ma, and G. Lajoie. Analysis of polypeptide ladders produced by microwave-induced acid hydrolysis of proteins with atmospheric pressre matrix-assited laser desorption/ionization-triple quadrupole Fourier Transform ion cyclotron resonance mass spectrometry (AP-MALDI-QFT). 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 3 H. Zhang, C. Zhang, G. A. Lajoie, and K. K.-C. Yeung. Selective sampling of phosphopeptides based on isoelectric point (pI) for ultra-sensitive MALDI MS analysis. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 4 J. Locke, J. Rogalski, L. Guo, B. Ma, J. Kast, and G. Lajoie. Automated de novo sequencing using ToF-ToF tandem MS data. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 5 W. Yang, C. Zhang, B. Ma, and G. Lajoie. SMASH: Software for identification of microwave-assisted-hydrolyzed proteins by MALDI-TOF MS. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 6 B. Ma and G. Lajoie. Improving the de novo sequencing accuracy by combining two independent scoring functions in PEAKS software. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 7 J. N. M. Ballard, H. Zhang, C. Zhang, K. K.-C. Yeung, and G. A. Lajoie. Sensitive phosphopeptide analysis: selective extraction and injection of phosphopeptides using capillary electrophoresis (CE) coupled ESI-MS. 53rd ASKS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 8 C. Zhang, A. Doherty-Kirby, M. Kahn, K. Emani, and G. Lajoie. A case study: Identification of three phosphorylation sites of adenoviral E1A-binding protein (p300) by LC-ESI-MS/MS. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 9 A. T. Booy, P. P. Pittock, J. L. Campbell, V. Han, and G. A. Lajoie. Establishment of the full term placental chorionic villous proteome by free flow electrophoresis and 2D SDS-PAGE. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 10 B. Shan, W. Chen, K. Zhang, B. Ma, C. Zhang, and G. Lajoie. Software for determining glycan structures from MS/MS spectra and structural alignment. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 11 S. Liu, Manzanares, A. Doherty-Kirby, F. Possmayer, and G. A. Lajoie. Mass spectrometric analysis of surfactant proteins. 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 2005. 12 S. C. Bendall, P. Pittock, M. Bhatia and G. Lajoie. A proteomic strategy to analyze secreted factors from cell culture. 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 2004. 13 B. Shan, K. Zhang, B. Ma, C. Zhang, and G Lajoie. GlycoMaster - A software for interpretation of glycopeptides from MS/MS spectra. 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 2004. 14 B. Ma, A. Doherty-Kirby, A. Booy, B. Olafson, and G. Lajoie. A comprehensive comparison of the de novo sequencing accuracy of PEAKS, Bioanalyst and PLGS. 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 2004. 15 C. Zhang, A Doherty-Kirby, R van Huystee, and G. Lajoie. Investigation of cationic peanut peroxidase glycans by electrospray ionization mass spectrometry. 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 2004. 16 H. Zhang, K. Zhang, B. Ma, C. Zhang, A. Doherty-Kirby, and G. Lajoie. FOOTPRINT: A new algorithm for charge state deconvolution of complex ESI mass spectra. 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 2004. 17 A. Doherty-Kirby, C. Zhang, M. Keykhosravani, D. Brewer, H. Goldberg; G. K. Hunter; G. Lajoie; Post-translational modification analysis of native rat bone osteopontin. 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 2004. 18 G. J. A. Vilk and G. Lajoie. Delineating the signaling pathway of histatin H5 in yeast. 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 2004. 19 T. Dobransky, A. Doherty-Kirby, D. Brewer, G. Lajoie, and R. J. Rylett. Identification of protein kinase-C isoform-specific phosphorylation sites of human choline acetyltransferase by mass spectrometry. HUPO 2nd Annual & IUBMB XIX Joint World Congress, Montreal, Quebec, October 2003. 20 A. Doherty-Kirby, M. Keykhosravani, D. Brewer, C. Zhang, H. Goldberg, G. K. Hunter, and G. Lajoie. Post-translational modification analysis of native rat bone osteopontin. HUPO 2nd Annual & IUBMB XIX Joint World Congress, Montreal, Quebec, October 2003. 21 M. Gupta, S. Liu, A. Doherty-Kirby, G. Lajoie, R. Gratton, D. Tardieu, and V. Han. Pathophysiology of intrauterine growth restriction (IUGR): a proteomics approach. HUPO 2nd Annual & IUBMB XIX Joint World Congress, Montreal, Quebec, October 2003. 22 D. K. Arrell, S. T. Elliot, M. Murata, H. A. Brown, A. Doherty-Kirby, G. A. Lajoie, E. Marban, and J. E. Van Eyk. Functional mechanistic convergence of the preconditioning agents adenosine and diazoxide at the level of oxidative metabolism. Scientific Conference on Molecular Mechanisms of Growth, Death, and Regeneration in the Myocardium: Basic Biology and Insights Into Ischemic Heart Disease and Heart Failure, Snowbird, Utah, August 2003. 23 M. Keykhosravani, A. Doherty-Kirby, G. Vilk, H. Goldberg, G. K. Hunter, and G. Lajoie. Localization of phosphorylated residues in rat bone osteopontin. 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 2003. 24 A. L. Doherty-Kirby, J. G. Guillemette, and G. A. Lajoie. Gas phase stability of protein-protein complexes. 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 8-12, 2003. 25 S. Heidelberger and G. Lajoie. Determination of potential protein binding targets of histatin 5 in Saccharomyces cerevisiae. 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 2003. 26 D. A. Simmons, S. D. Dunn, A. Doherty-Kirby, G. Lajoie, and L. Konermann. Myoglobin conformational dynamics studied by ESI-MS and H/D exchange. 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 2003. 27 L. Graham, D. Brewer, M.J. Kuiper, G. Lajoie, and P. Davies. Characterization of a beetle odorant binding protein family by tandem mass spectrometry and cDNA cloning. 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2002. 28 B. Ma, K. Zhang, M. Li, A. Doherty-Kirby and G. Lajoie. A powerful software tool for the de novo sequencing of peptides from MS/MS data. 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2002. 29 L. Graham, D. Brewer, P. Davies, and G. Lajoie. Identification of novel ordorant binding proteins in the beetle Tenebrio molitor. 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2002. 30 A. Doherty-Kirby and G. Lajoie. ESI-MS of serine protease inhibitors complexes: A site directed mutagenesis study. 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2002. 31 S. E. Dale, A. Dohery-Kirby, G. Lajoie and D. E. Heinrichs. Identification and characterization of as siderophore biosynthetic operon in Staphylococcus aureus. American Society for Microbiology, Salt Lake City, Utah, May 2002. 32 M. Wrona and G. Lajoie. A new strategy for the synthesis of short cyclic peptides. IUPAC Bioorganic Chemistry International Meeting, Toronto, August 2002
1 C. Zhang, A. Doherty-Kirby, R. B. van Huystee, and G. Lajoie. Characterization of the N-linked glycans of cationic peanut peroxidase. Proteome Society Meeting, Toronto, ON, November, 2003. 2 G. Vilk, S. Sarno, L. A. Pinna, G. A. Lajoie, and D. W. Litchfield. Protein kinase CK2 catalyses tyrosine phosphorylation in mammalian cells. The 3rd International Conference of the Canadian Proteomics Initiative, Vancouver, BC. May 2003. Last updated October 31, 2005 (ADK).
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