Calcium-binding Proteins (selected publications)
Link to all Calcium-binding Protein publications
Stocks B.B., Rezvanpour A., Shaw G.S. & Konermann L. (2011) Temporal Development of Protein Structure during S100A11 Folding and Dimerization Probed by Oxidative Labeling and Mass Spectrometry. J Mol Biol. 409, 669-679. Pubmed
Santamaria-Kisiel L. & Shaw GS. (2011) Identification of regions responsible for the open conformation of S100A10 using chimaeric S100A11-S100A10 proteins. Biochem J. 434, 37-48. Pubmed
Marlatt N.M., Spratt D.E. & Shaw G.S. (2010) Codon optimization for enhanced Escherichia coli expression of human S100A11 and S100A1 proteins. Protein Expr. Purif. 73, 58-64. Pubmed
Rezvanpour A. & Shaw G.S. (2009) Unique S100 Target Protein Interactions. Gen. Physiol. Biophys., Focus Issue, 28, 39-46.
Rezvanpour A., Phillips J.M. & Shaw G.S. (2009) Design of high-affinity S100-target hybrid proteins. Protein Sci.18, 2528-2536. Pubmed
Marlatt N.M., Boys B.L., Konermann L. & Shaw G.S. (2009) Formation of Monomeric S100B and S100A11 Proteins at Low Ionic Strength (dagger). Biochemistry 48, 1954-1963. Pubmed
Rintala-Dempsey A.C., Rezvanpour A. & Shaw G.S. (2008) S100-annexin complexes - structural insights. FEBS J. 275, 4956-4966. Pubmed
Shaw G.S., Marlatt N.M., Ferguson P.L., Barber K.R. & Bottomley S.P. (2008) Identification of a dimeric intermediate in the unfolding pathway for the calcium-binding protein S100B. J. Mol. Biol. 382, 1075-1088. Pubmed
Malik S., Revington M., Smith S.P. & Shaw G.S. (2008) Analysis of the structure of human apo-S100B at low temperature indicates a unimodal conformational distribution is adopted by calcium-free S100 proteins. Proteins 73, 28-42. Pubmed
Marlatt N.M. & Shaw G.S. (2007) Amide exchange shows calcium-induced conformational changes are transmitted to the dimer interface of S100B. Biochemistry 46, 7478-7487. Pubmed
Rintala-Dempsey A.C., Santamaria-Kisiel L., Liao Y., Lajoie G. & Shaw G.S. (2006) Insights into S100 target specificity examined by a new interaction between S100A11 and annexin A2. Biochemistry 45, 14695 -14705. Pubmed
Santamaria-Kisiel L., Rintala-Dempsey
A.C. & Shaw G.S. (2006) Calcium-dependent and -independent interactions
of the S100 protein family.
Biochem. J. 396, 201–214. Pubmed
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Pan J., Rintala-Dempsey A.C., Li Y., Shaw G.S. & Konermann L. (2006) Folding Kinetics of the S100A11 Protein Dimer Studied by Time-Resolved Electrospray Mass Spectrometry and Pulsed Hydrogen-Deuterium Exchange. Biochemistry 45, 3005 -3013. Pubmed
Protein Interactions in Degradation and Parkinson's Disease
(selected publications)
Link to all Protein Interaction publications
Chaugule V.K., Burchell L., Barber K.R., Sidhu A., Leslie S.J., Shaw G.S. & Walden H. (2011) Autoregulation of Parkin activity through its ubiquitin-like domain. EMBO J. Pubmed
Safadi S.S., Barber K.R. & Shaw G.S. (2011) Impact of autosomal recessive juvenile Parkinson's disease mutations on the structure and interactions of the parkin ubiquitin-like domain. Biochemistry 50, 2603-2610. Pubmed
Spratt D.E. & Shaw G.S. (2011) Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin. J Mol Biol. 407, 425-438. Pubmed
Serniwka S.A., & Shaw G.S. (2009) Structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site. Biochemistry 48, 12169-12179. Pubmed
Safadi S.S. & Shaw G.S. (2009) Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15. J. Biol. Chem. 285, 1424-1434. Pubmed
Hristova V.A., Beasley S.A., Rylett R.J. & Shaw G.S. (2009) Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile parkinson's related E3 ligase parkin. J. Biol. Chem. 284, 14978-14986. Pubmed
Serniwka S.A., & Shaw G.S. (2008) 1H, 13C and 15N resonance assignments for the human E2 conjugating enzyme, UbcH7. Biomol. NMR Assign. 2, 21-23. Pubmed
Safadi S.S. & Shaw G.S. (2007) A disease state mutation unfolds the parkin ubiquitin-like domain. Biochemistry 46, 14162-14169. Pubmed
Beasley S.A., Hristova V.A. & Shaw G.S. (2007) Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson’s disease. PNAS 104, 3095-3100. Pubmed
Merkley N., Barber K.R. & Shaw G.S. (2005) Ubiquitin Manipulation by an E2 Conjugating Enzyme Using a Novel Covalent Intermediate. J. Biol. Chem. 280, 31732-31738. Pubmed
Merkley N. & Shaw G.S. (2004) Solution Structure of the Flexible Class II Ubiquitin-Conjugating Enzyme Ubc1 Provides Insights for Polyubiquitin Chain Assembly. J. Biol. Chem. 279, 47139-47147. Pubmed
Collaborative Projects
Duncan K.E., Dempsey B.R., Killip L.E., Adams J., Bailey M.L., Lajoie G.A., Litchfield D.W., Brandl C.J., Shaw G.S. & Shilton B.H. (2011) Discovery and characterization of a nonphosphorylated cyclic Peptide inhibitor of the peptidylprolyl isomerase, pin1. J. Med. Chem. 54, 3854-3865. Pubmed
Yousef A.F., Fonseca G.J., Pelka P., Ablack J.N., Walsh C., Dick F.A., Bazett-Jones D.P., Shaw G.S. & Mymryk J.S. (2010) Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation. Oncogene 29, 4693-4704. Pubmed
Butty F.D., Aucoin M., Morrison L., Ho N., Shaw G. & Creuzenet C. (2009) Elucidating the formation of 6-deoxyheptose: biochemical characterization of the GDP-D-glycero-d-manno-heptose C6 dehydratase, DmhA, and its associated C4 reductase, DmhB. Biochemistry 48, 7764-7775. Pubmed
Revington M., Semesi A., Yee A., Arrowsmith C.H. & Shaw G.S. (2006) The solution structure of the protein ydhA from Escherichia coli. J. Biomol. NMR. 35, 295-300. Pubmed
Revington M., Semesi A., Yee A. & Shaw G.S. (2005) Solution Structure of the Escherichia coli Protein ydhR: A Putative Mono-oxygenase. Protein Science 14, 3115-3120. Pubmed
Dempsey B., Wrona M., Moulin J.M., Gloor G.B., Jalilehvand F., Lajoie G., Shaw G.S. & Shilton B.H. (2004) Structure of the C-Terminal Domain of the SecA ATPase. Biochemistry 43, 9361-9671. Pubmed
Revington M., Dunn S.D & Shaw G.S. (2002) Folding and Stability of the b Subunit of the F(1)F(0) ATP Synthase. Protein Science 11, 1227-1238. Pubmed
Hung L-H., Chaconas G. & Shaw G.S. (2000) The Solution Structure of the C-terminal Domain of the Mu B Transposition Protein. EMBO J. 19, 5625-5634. Pubmed
