research

 

Recent Publications from Faculty in the Dept. of Biochemistry

 

Jan 2012
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 Jan 2011   Feb 2011   Mar 2011   Apr 2011   May 2011   June 2011

July 2011   Aug 2011   Sept 2011   Oct 2011   Nov 2011   Dec 2011
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2004-2010 (PDF)

Link to Scholarship@Western for more faculty publications


 

structure of PCNA complex

 

Structure of PCNA complex determined by X-ray crystallography
 (Dr. Ling's lab at Western).

Jan 2012

  1. McGee J, Kotsopoulos J, Lubinski J, Lynch HT, Rosen B, Tung N, Kim-Sing C, Karlan B, Foulkes WD, Ainsworth P, Ghadirian P, Senter L, Eisen A, Sun P, Narod SA. Anthropometric Measures and Risk of Ovarian Cancer Among BRCA1 and BRCA2 Mutation Carriers. Obesity (Silver Spring). 2012 Jan 19.
  2. Zalewski A, Cecchini EL, Deroo BJ. Expression of Extracellular Matrix Components Is Disrupted in the Immature and Adult Estrogen Receptor β-Null Mouse Ovary. PLoS One. 2012;7(1):e29937. Epub 2012 Jan 10.
  3. Coschi CH, Dick FA. Chromosome instability and deregulated proliferation: an unavoidable duo. Cell Mol Life Sci. 2012 Jan 6.
  4. Cecchini MJ, Amiri M, Dick FA. Analysis of cell cycle position in Mammalian cells. J Vis Exp. 2012 Jan 21;(59).
  5. Peart TM, Correa RJ, Valdes YR, Dimattia GE, Shepherd TG. BMP signalling controls the malignant potential of ascites-derived human epithelial ovarian cancer spheroids via AKT kinase activation. Clin Exp Metastasis. 2012 Jan 17.
  6. Li L, Tibiche C, Fu C, Kaneko T, Moran MF, Schiller MR, Li SS, Wang E. The human phosphotyrosine signaling network: Evolution and hotspots of hijacking in cancer. Genome Res. 2012 Jan 26.
  7. Surendran RP, Visser ME, Heemelaar S, Wang J, Peter J, Defesche JC, Kuivenhoven JA, Hosseini M, Péterfy M, Kastelein JJ, Johansen CT, Hegele RA, Stroes ES, Dallinga-Thie GM. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia. J Intern Med. 2012 Jan 12.
  8. Basel-Vanagaite L, Zevit N, Zahav AH, Guo L, Parathath S, Pasmanik-Chor M, McIntyre AD, Wang J, Albin-Kaplanski A, Hartman C, Marom D, Zeharia A, Badir A, Shoerman O, Simon AJ, Rechavi G, Shohat M, Hegele RA, Fisher EA, Shamir R. Transient Infantile Hypertriglyceridemia, Fatty Liver, and Hepatic Fibrosis Caused by Mutated GPD1, Encoding Glycerol-3-Phosphate Dehydrogenase 1. Am J Hum Genet. 2012 Jan 4.
  9. Rabeh WM, Bossard F, Xu H, Okiyoneda T, Bagdany M, Mulvihill CM, Du K, di Bernardo S, Liu Y, Konermann L, Roldan A, Lukacs GL. Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function. Cell. 2012 Jan 20;148(1-2):150-63.
  10. Market Velker BA, Denomme MM, Mann MR. Loss of Genomic Imprinting in Mouse Embryos with Fast Rates of Preimplantation Development in Culture. Biol Reprod. 2012 Jan 25.
  11. Turley EA, Naor D. RHAMM and CD44 peptides-analytic tools and potential drugs. Front Biosci. 2012 Jan 1;17:1775-94.

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Dec 2011

  1. Chandok N, Speechley M, Ainsworth PJ, Chakrabarti S, Adams PC. The Impact of Population-Based Screening Studies on Hemochromatosis Screening Practices. Dig Dis Sci. 2011 Dec 10.
  2. Carnevale J, Palander O, Seifried LA, Dick FA. DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol. 2011 Dec 19.
  3. Johansen CT, Wang J, McIntyre AD, Martins RA, Ban MR, Lanktree MB, Huff MW, Péterfy M, Mehrabian M, Lusis AJ, Kathiresan S, Anand SS, Yusuf S, Lee AH, Glimcher LH, Cao H, Hegele RA. Excess of Rare Variants in Non-GWAS Candidate Genes in Patients with Hypertriglyceridemia. Circ Cardiovasc Genet. 2011 Dec 1.
  4. Huang L, Szymanska K, Jensen VL, Janecke AR, Innes AM, Davis EE, Frosk P, Li C, Willer JR, Chodirker BN, Greenberg CR, McLeod DR, Bernier FP, Chudley AE, Müller T, Shboul M, Logan CV, Loucks CM, Beaulieu CL, Bowie RV, Bell SM, Adkins J, Zuniga FI, Ross KD, Wang J, Ban MR, Becker C, Nürnberg P, Douglas S, Craft CM, Akimenko MA, Hegele RA, Ober C, Utermann G, Bolz HJ, Bulman DE, Katsanis N, Blacque OE, Doherty D, Parboosingh JS, Leroux MR, Johnson CA, Boycott KM. TMEM237 Is Mutated in Individuals with a Joubert Syndrome Related Disorder and Expands the Role of the TMEM Family at the Ciliary Transition Zone. Am J Hum Genet. 2011 Dec 9;89(6):713-30.
  5. St Amant AH, Hudson RH. Synthesis and oligomerization of Fmoc/Boc-protected PNA monomers of 2,6-diaminopurine, 2-aminopurine and thymine. Org Biomol Chem. 2011 Dec 12.
  6. Ahadi E, Konermann L. Modeling the Behavior of Coarse-Grained Polymer Chains in Charged Water Droplets: Implications for the Mechanism of Electrospray Ionization. J Phys Chem B. 2011 Dec 12.
  7. Pan Y, Piyadasa H, O'Neil JD, Konermann L. Conformational Dynamics of a Membrane Transport Protein Probed by H/D Exchange and Covalent Labeling: The Glycerol Facilitator. J Mol Biol. 2011 Dec 29.
  8. Zhang J, Xin L, Shan B, Chen W, Xie M, Yuen D, Zhang W, Zhang Z, Lajoie GA, Ma B. PEAKS DB: De Novo sequencing assisted database search for sensitive and accurate peptide identification. Mol Cell Proteomics. 2011 Dec 20.
  9. Prasad C, Cairney AE, Rosenblatt DS, Rupar CA. Transcobalamin (TC) deficiency and newborn screening. J Inherit Metab Dis. 2011 Dec 14.
  10. D'Alessandro LC, Siu VM, Casey B. Situs Inversus Totalis and a Novel ZIC3 Mutation in a Family with X-linked Heterotaxy. Congenit Heart Dis. 2011 Dec 16.

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Nov 2011

  1. Cino EA, Wong-ekkabut J, Karttunen M, Choy W-Y (2011) Microsecond Molecular Dynamics Simulations of Intrinsically Disordered Proteins Involved in the Oxidative Stress Response. PLoS ONE 6(11): e27371.
  2. Hummelen R, Macklaim JM, Bisanz JE, Hammond JA, McMillan A, Vongsa R, Koenig D, Gloor GB, Reid G. Vaginal microbiome and epithelial gene array in post-menopausal women with moderate to severe dryness. PLoS One. 2011;6(11):e26602.
  3. Torres AG, Fabani MM, Vigorito E, Williams D, Al-Obaidi N, Wojciechowski F, Hudson RH, Seitz O, Gait MJ. Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs. Nucleic Acids Res. 2011 Nov 8.
  4. Milne M, Chicas K, Li A, Bartha R, Hudson RH. ParaCEST MRI contrast agents capable of derivatization via"click" chemistry. Org Biomol Chem. 2011 Nov 8.
  5. Pan Y, Brown LS, Konermann L. Hydrogen Exchange Mass Spectrometry of Bacteriorhodopsin Reveals Light-Induced Changes in the Structural Dynamics of a Biomolecular Machine. J Am Chem Soc. 2011 Nov 1.
  6. Pan J, Heath BL, Jockusch RA, Konermann L. Structural Interrogation of Electrosprayed Peptide Ions by Gas-Phase H/D Exchange and Electron Capture Dissociation Mass Spectrometry. Anal Chem. 2011 Nov 30.
  7. Kreutzer JN, Salvador A, Diana P, Cirrincione G, Vedaldi D, Litchfield DW, Issinger OG, Guerra B. 2-Triazenoazaindoles: Α novel class of triazenes inducing transcriptional down-regulation of EGFR and HER-2 in human pancreatic cancer cells. Int J Oncol. 2011 Nov 29.
  8. Valencia T, Joseph A, Kachroo N, Darby S, Meakin S, Gnanapragasam VJ. Role and expression of FRS2 and FRS3 in prostate cancer. BMC Cancer. 2011 Nov 11;11(1):484.
  9. Veiseh M, Breadner D, Ma J, Akentieva N, Savani RC, Harrison RE, Mikilus D, Collis L, Gustafson S, Lee TY, Koropatnick J, Luyt LG, Bissell MJ, Turley EA. Imaging of homeostatic, neoplastic and injured tissues by HA-based probes. Biomacromolecules. 2011 Nov 9.

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Oct 2011

  1. Rodenhiser DI, Bérubé NG, Mann MR. Epigenetics, Eh!: A meeting summary of the Canadian Conference on Epigenetics. Epigenetics. 2011 Oct 1;6(10).
  2. Correa RJ, Peart T, Valdes YR, Dimattia GE, Shepherd TG. Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids. Carcinogenesis. 2011 Oct 31.
  3. Johansen CT, Hegele RA. Allelic and phenotypic spectrum of plasma triglycerides. Biochim Biophys Acta. 2011 Oct 12.
  4. Sciuto SV, Liu J, Konermann L. An electrostatic charge partitioning model for the dissociation of protein complexes in the gas phase. J Am Soc Mass Spectrom. 2011 Oct;22(10):1679-89.
  5. Li L, Zhao B, Du J, Zhang K, Ling CX, Li SS. DomPep-A General Method for Predicting Modular Domain-Mediated Protein-Protein Interactions. PLoS One. 2011;6(10):e25528.
  6. Xu H, Kongmanas K, Kadunganattil S, Smith CE, Rupar T, Goto-Inoue N, Hermo L, Faull KF, Tanphaichitr N. Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells. J Lipid Res. 2011 Oct 6.
  7. Fell VL, Schild-Poulter C. Ku regulates signaling to DNA damage response pathways through the Ku70 vWA domain. Mol Cell Biol. 2011 Oct 28.
  8. McCallum M, Shaw GS, Creuzenet C. Characterization of the dehydratase WcbK and the reductase WcaG involved in GDP-6-deoxy-manno-heptose biosynthesis in Campylobacter jejuni. Biochem J. 2011 Oct 15;439(2):235-48.
  9. Price MA, Wanshura LE, Yang J, Carlson J, Xiang B, Li G, Ferrone S, Dudek AZ, Turley EA, McCarthy JB. CSPG4, a Potential Therapeutic Target, Facilitates Malignant Progression of Melanoma. Pigment Cell Melanoma Res. 2011 Oct 17.

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Sept 2011

  1. Tanabe N, Wheal BD, Kwon J, Chen HH, Shugg RP, Sims SM, Goldberg HA, Dixon SJ. Osteopontin signals through Calcium-NFAT in osteoclasts: A novel RGD-dependent pathway promoting cell survival. J Biol Chem. 2011 Sep 22.
  2. O'Young J, Liao Y, Xiao Y, Jalkanen J, Lajoie GA, Karttunen M, Goldberg HA, Hunter GK. Matrix Gla Protein Inhibits Ectopic Calcification by a Direct Interaction with Hydroxyapatite Crystals. J Am Chem Soc. 2011 Sep 30.
  3. Mancini GB, Baker S, Bergeron J, Fitchett D, Frohlich J, Genest J, Gupta M, Hegele RA, Ng D, Pope J. Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a canadian working group consensus conference. Can J Cardiol. 2011 Sep;27(5):635-62.
  4. Gangloff A, Bergeron J, Couture P, Martins R, Hegele RA, Gagné C. A novel mutation of apolipoprotein B in a French Canadian family with homozygous hypobetalipoproteinemia. J Clin Lipidol. 2011 Sep;5(5):414-7.
  5. Lahiry P, Lee LJ, Frey BJ, Rupar CA, Siu VM, Blencowe BJ, Hegele RA. Transcriptional profiling of endocrine cerebro-osteodysplasia using microarray and next-generation sequencing. PLoS One. 2011;6(9):e25400.
  6. Iyer H, Sen M, Prasad C, Rupar CA, Lindsay RM. Coma, hyperammonemia, metabolic acidosis, and mutation: Lessons learned in the acute management of late onset urea cycle disorders. Hemodial Int. 2011 Sep 19.
  7. Swanick KN, Dodd DW, Price JT, Brazeau AL, Jones ND, Hudson RH, Ding Z. Electrogenerated chemiluminescence of triazole-modified deoxycytidine analogues in N,N-dimethylformamide. Phys Chem Chem Phys. 2011 Sep 1.
  8. Moustafa ME, Hudson RH. An Azo-Based PNA Monomer: Synthesis and Spectroscopic Study. Nucleosides Nucleotides Nucleic Acids. 2011 Sep;30(9):740-51.
  9. Kennedy KA, Sandiford SD, Skerjanc IS, Li SS. Reactive oxygen species and the neuronal fate. Cell Mol Life Sci. 2011 Sep 23.
  10. Gyenis L, Duncan JS, Turowec JP, Bretner M, Litchfield DW. Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2. J Proteome Res. 2011 Sep 21.
  11. Duncan JS, Haystead TA, Litchfield DW. Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP. Methods Mol Biol. 2012;795:119-34.
  12. Leung KK, Litchfield DW, Shilton BH. Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure-function studies. Anal Biochem. 2011 Sep 16.
  13. Nong Z, O'Neil C, Lei M, Gros R, Watson A, Rizkalla A, Mequanint K, Li S, Frontini MJ, Feng Q, Geoffrey Pickering J. Type I Collagen Cleavage Is Essential for Effective Fibrotic Repair after Myocardial Infarction. Am J Pathol. 2011 Sep 8.
  14. Prasad C, Rupar T, Prasad AN. Pyruvate dehydrogenase deficiency and epilepsy. Brain Dev. 2011 Sep 9.
  15. Prasad AN, Levin S, Rupar CA, Prasad C. Menkes disease and infantile epilepsy. Brain Dev. 2011 Sep 15.
  16. Dempsey BR, Shaw GS. Identification of Calcium-Independent and Calcium-Enhanced Binding Between S100B and the Dopamine D2 Receptor. Biochemistry. 2011 Sep 20.
  17. Rezvanpour A, Santamaria-Kisiel L, Shaw GS. The S100A10-annexin A2 complex provides a novel asymmetric platform for membrane repair. J Biol Chem. 2011 Sep 26.
  18. Thomadaki K, Helmerhorst EJ, Tian N, Sun X, Siqueira WL, Walt DR, Oppenheim FG. Whole-saliva Proteolysis and Its Impact on Salivary Diagnostics. J Dent Res. 2011 Sep 13.
  19. Vukosavljevic D, Custodio W, Siqueira WL. Salivary proteins as predictors and controls for oral health. J Cell Commun Signal. 2011 Sep 18.
  20. Siqueira WL, Dawes C. The salivary proteome: challenges and perspectives. Proteomics Clin Appl. 2011 Sep 28.
  21. Corkery D, Thillainadesan G, Coughlan N, Mohan R, Isovic M, Tini M, Torchia J. Regulation of the BRCA1 gene by an SRC3/53BP1 complex. BMC Biochem. 2011 Sep 13;12(1):50.

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Aug 2011

  1. Bérubé NG. ATRX in chromatin assembly and genome architecture during development and disease. Biochem Cell Biol. 2011 Aug 18.
  2. Kleinstiver BP, Bérubé-Janzen W, Fernandes AD, Edgell DR. Divalent Metal Ion Differentially Regulates the Sequential Nicking Reactions of the GIY-YIG Homing Endonuclease I-BmoI. PLoS One. 2011;6(8):e23804.
  3. Alabousi A, Al-Attar S, Joy TR, Hegele RA, McKenzie CA. Evaluation of adipose tissue volume quantification with IDEAL fat-water separation. J Magn Reson Imaging. 2011 Aug;34(2):474-9.
  4. Rabi DM, Daskalopoulou SS, Padwal RS, Khan NA, Grover SA, Hackam DG, Myers MG, McKay DW, Quinn RR, Hemmelgarn BR, Cloutier L, Bolli P, Hill MD, Wilson T, Penner B, Burgess E, Lamarre-Cliché M, McLean D, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Chockalingam A, Rabkin SW, Dawes M, Touyz RM, Burns KD, Ruzicka M, Campbell NR, Vallée M, Prasad GV, Lebel M, Campbell TS, Lindsay MP, Herman RJ, Larochelle P, Feldman RD, Arnold JM, Moe GW, Howlett JG, Trudeau L, Bacon SL, Petrella RJ, Lewanczuk R, Stone JA, Drouin D, Boulanger JM, Sharma M, Hamet P, Fodor G, Dresser GK, Carruthers SG, Pylypchuk G, Gilbert RE, Leiter LA, Jones C, Ogilvie RI, Woo V, McFarlane PA, Hegele RA, Poirier L, Tobe SW; Canadian Hypertension Education Program. The 2011 canadian hypertension education program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol. 2011 Jul-Aug;27(4):415-433.e2.
  5. Hughes CS, Nuhn AA, Postovit LM, Lajoie GA. Proteomics of human embryonic stem cells. Proteomics Clin Appl. 2011 Aug;5(7-8):476.
  6. Hughes CS, Radan L, Betts D, Postovit LM, Lajoie GA. Proteomic Analysis of Extracellular Matrices used in Human Embryonic Stem Cell Culture. Proteomics. 2011 Aug 10.
  7. Steinbach SK, El-Mounayri O, Dacosta RS, Frontini MJ, Nong Z, Maeda A, Pickering JG, Miller FD, Husain M. Directed Differentiation of Skin-Derived Precursors Into Functional Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2011 Aug 18.
  8. Gros R, Ding Q, Davis M, Shaikh R, Liu B, Chorazyczewski J, Pickering JG, Feldman RD. Delineating the receptor mechanisms underlying the rapid vascular contractile effects of aldosterone and estradiol. Can J Physiol Pharmacol. 2011 Sep;89(9):655-63. Epub 2011 Aug 19.
  9. Khan WA, Knoll JH, Rogan PK. Context-based FISH localization of genomic rearrangements within chromosome 15q11.2q13 duplicons. Mol Cytogenet. 2011 Aug 8;4(1):15.

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July 2011

  1. Christie DA, Lemke CD, Elias IM, Chau LA, Kirchhof MG, Li B, Ball EH, Dunn SD, Hatch GM, Madrenas J. Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. Mol Cell Biol. 2011 Jul 11.
  2. Takeuchi R, Lambert AR, Mak AN, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL. Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc Natl Acad Sci U S A. 2011 Jul 22.
  3. Turowec JP, Duncan JS, Gloor GB, Litchfield DW. Regulation of caspase pathways by protein kinase CK2: identification of proteins with overlapping CK2 and caspase consensus motifs. Mol Cell Biochem. 2011 Jul 13.
  4. Milne M, Hudson RH. Contrast agents possessing high temperature sensitivity. Chem Commun (Camb). 2011 Jul 11.
  5. Golding MC, Magri LS, Zhang L, Lalone SA, Higgins MJ, Mann MR. Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells. Development. 2011 Jul 20.
  6. Denomme MM, Zhang L, Mann MR. Embryonic imprinting perturbations do not originate from superovulation-induced defects in DNA methylation acquisition. Fertil Steril. 2011 Jul 20.
  7. Prasad AN, Rupar CA, Prasad C. Methylenetetrahydrofolate reductase (MTHFR) deficiency and infantile epilepsy. Brain Dev. 2011 Jul 19.
  8. Todorovic B, Massimi P, Hung K, Shaw GS, Banks L, Mymryk JS. Systematic analysis of the amino acid residues of human papillomavirus 16 E7 conserved region 3 involved in dimerization and transformation. J Virol. 2011 Jul 20.

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June 2011

  1. Pelka P, Miller MS, Cecchini M, Yousef AF, Bowdish DM, Dick F, Whyte P, Mymryk JS. Adenovirus E1A directly targets the E2F/DP-1 complex. J Virol. 2011 Jun 29.
  2. Austin SE, Hegele RA. Clinical Implications of Direct-to-Consumer Genetic Testing for Cardiovascular Disease Risk. Can J Cardiol. 2011 Jun 6.
  3. Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med. 2011 Jun 12.
  4. Wahba AS, Azizi F, Deleavey GF, Brown C, Robert F, Carrier M, Kalota A, Gewirtz A, Pelletier J, Hudson RH, Damha MJ. Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA. ACS Chem Biol. 2011 Jun 13.
  5. Suchý M, Elmehriki AA, Hudson RH. A Remarkably Simple Protocol for the N-Formylation of Amino Acid Esters and Primary Amines. Org Lett. 2011 Jun 28.
  6. Pan J, Han J, Borchers CH, Konermann L. Conformer-Specific Hydrogen Exchange Analysis of Abeta(1-42) Oligomers by Top-Down Electron Capture Dissociation Mass Spectrometry. Anal Chem. 2011 Jun 2.
  7. Konermann L, Pan Y, Stocks BB. Protein folding mechanisms studied by pulsed oxidative labeling and mass spectrometry. Curr Opin Struct Biol. 2011 Jun 22.
  8. St-Denis NA, Bailey ML, Parker EL, Vilk G, Litchfield DW. Localization of phosphorylated CK2{alpha} to the mitotic spindle requires the peptidyl-prolyl isomerase Pin1. J Cell Sci. 2011 Jun 21.
  9. Graves LM, Litchfield DW. "Going KiNativ": Probing the Native Kinome. Chem Biol. 2011 Jun 24;18(6):683-4.
  10. Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H. Autoregulation of Parkin activity through its ubiquitin-like domain. EMBO J. 2011 Jun 21. doi: 10.1038/emboj.2011.204.
  11. McCallum M, Shaw GS, Creuzenet C. Characterization of the dehydratase WcbK and the reductase WcaG involved in GDP-6-deoxy-manno-heptose biosynthesis in Campylobacter jejuni. Biochem J. 2011 Jun 28.
  12. Costa JF, Siqueira WL, Loguercio AD, Reis A, Oliveira E, Alves CM, Bauer JR, Grande RH. Characterization of aqueous silver nitrate solutions for leakage tests. J Appl Oral Sci. 2011 Jun;19(3):254-9.
  13. Lehalle D, Williams C, Siu VM, Clayton-Smith J. Fetal pads as a clue to the diagnosis of Pitt-Hopkins syndrome. Am J Med Genet A. 2011 Jun 10.
  14. Booker CJ, Sun S, Woolsey S, Mejia JS, Yeung KK. Removal of sample background buffering ions and myoglobin enrichment via a pH junction created by discontinuous buffers in capillary electrophoresis. J Chromatogr A. 2011 Jun 22.

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May 2011

  1. Bordeleau L, Lipscombe L, Lubinski J, Ghadirian P, Foulkes WD, Neuhausen S, Ainsworth P, Pollak M, Sun P, Narod SA; the Hereditary Breast Cancer Clinical Study Group. Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations. Cancer. 2011 May 1;117(9):1812-1818.
  2. Stead BE, Brandl CJ, Davey MJ. Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damage. Nucleic Acids Res. 2011 May 19.
  3. Duncan KE, Dempsey BR, Killip LE, Adams J, Bailey ML, Lajoie GA, Litchfield DW, Brandl CJ, Shaw GS, Shilton BH. Discovery and Characterization of a Nonphosphorylated Cyclic Peptide Inhibitor of the Peptidylprolyl Isomerase, Pin1. J Med Chem. 2011 May 5.
  4. Dick FA, Mymryk JS. Sweet DREAMs for Hippo. Genes Dev. 2011 May 1;25(9):889-94.
  5. Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL. Stanniocalcin 2 alters PERK signaling and reduces cellular injury during cerulein induced pancreatitis in mice. BMC Cell Biol. 2011 May 5;12(1):17.
  6. Duncan JS, Turowec JP, Duncan KE, Vilk G, Wu C, Lüscher B, Li SS, Gloor GB, Litchfield DW. A Peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling. Sci Signal. 2011 May 10;4(172):ra30.
  7. Grohe B, O'Young J, Langdon A, Karttunen M, Goldberg HA, Hunter GK. Citrate Modulates Calcium Oxalate Crystal Growth by Face-Specific Interactions. Cells Tissues Organs. 2011 May 9.
  8. Liu D, Haniford DB, Chalmers RM. H-NS mediates the dissociation of a refractory protein-DNA complex during Tn10/IS10 transposition. Nucleic Acids Res. 2011 May 11.
  9. Johansen CT, Wang J, Hegele RA. Bias due to selection of rare variants using frequency in controls. Nat Genet. 2011 May;43(5):394-5.
  10. Johansen CT, Wang J, Lanktree MB, McIntyre AD, Ban MR, Martins RA, Kennedy BA, Hassell RG, Visser ME, Schwartz SM, Voight BF, Elosua R, Salomaa V, O'Donnell CJ, Dallinga-Thie GM, Anand SS, Yusuf S, Huff MW, Kathiresan S, Cao H, Hegele RA. An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2011 May 19.
  11. Ahadi E, Konermann L. Ejection of Solvated Ions from Electrosprayed Methanol/Water Nanodroplets Studied by Molecular Dynamics Simulations. J Am Chem Soc. 2011 May 18.
  12. Pan Y, Brown L, Konermann L. Kinetic Folding Mechanism of an Integral Membrane Protein Examined by Pulsed Oxidative Labeling and Mass Spectrometry. J Mol Biol. 2011 May 6.
  13. Kirouac KN, Ling H. Pol iota: Shining light on repair of oxidative DNA lesions and mutations. Cell Cycle. 2011 May 15;10(10):1-2.
  14. Espinosa-Tanguma R, O'Neil C, Chrones T, Pickering JG, Sims SM. Essential Role for Calcium Waves in Migration of Human Vascular Smooth Muscle Cells. Am J Physiol Heart Circ Physiol. 2011 May 13.
  15. Matos R, Novaes TF, Braga MM, Siqueira WL, Duarte DA, Mendes FM. Clinical Performance of Two Fluorescence-Based Methods in Detecting Occlusal Caries Lesions in Primary Teeth. Caries Res. 2011 May 31;45(3):294-302.

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Apr 2011

  1. Mucaki EJ, Ainsworth P, Rogan PK. Comprehensive prediction of mRNA splicing effects of BRCA1 and BRCA2 variants. Hum Mutat. 2011 Apr 26.
  2. Edgell DR, Chalamcharla VR, Belfort M. Learning to live together: mutualism between self-splicing introns and their hosts. BMC Biol. 2011 Apr 11;9:22.
  3. Dubé JB, Johansen CT, Hegele RA. Sortilin: An unusual suspect in cholesterol metabolism: From GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism. Bioessays. 2011 Apr 4.
  4. Johansen CT, Hegele RA. Genetic bases of hypertriglyceridemic phenotypes. Curr Opin Lipidol. 2011 Apr 23.
  5. Dodd DW, Damjanovski S, Hudson RE. Peptide Nucleic Acid Pt(II) Conjugates: A Preliminary Study of Antisense Effects in Xenopus laevis. Nucleosides Nucleotides Nucleic Acids. 2011 Apr;30(4):257-63.
  6. Mulvihill EE, Assini JM, Lee JK, Allister EM, Sutherland BG, Koppes JB, Sawyez CG, Edwards JY, Telford DE, Charbonneau A, St-Pierre P, Marette A, Huff MW. Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance. Diabetes. 2011 Apr 6.
  7. Stocks BB, Rezvanpour A, Shaw GS, Konermann L. Temporal Development of Protein Structure during S100A11 Folding and Dimerization Probed by Oxidative Labeling and Mass Spectrometry. J Mol Biol. 2011 Apr 16.
  8. Zheng Y, Qin H, Frank SJ, Deng L, Litchfield DW, Tefferi A, Pardanani A, Lin FT, Li J, Sha B, Benveniste EN. A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway. Blood. 2011 Apr 28.
  9. Frontini MJ, Nong Z, Gros R, Drangova M, O'Neil C, Rahman MN, Akawi O, Yin H, Ellis CG, Pickering JG. Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells. Nat Biotechnol. 2011 Apr 17.

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Mar 2011

  1. Liu J, Konermann L. Protein-protein binding affinities in solution determined by electrospray mass spectrometry. J Am Soc Mass Spectrom. 2011 Mar;22(3):408-17.
  2. Shen SL, Qiu FH, Dayarathna TK, Wu J, Kuang M, Li SS, Peng BG, Nie J. Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration. Biochim Biophys Acta. 2011 Mar 17.
  3. Golding MC, Mann MR. A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells. Gene Ther. 2011 Mar 10.
  4. Telmer PG, Tolg C, McCarthy JB, Turley EA. How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression? Commun Integr Biol. 2011 Mar;4(2):182-5.

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Feb 2011

  1. Wächter A, Bi Y, Dunn SD, Cain BD, Sielaff H, Wintermann F, Engelbrecht S, Junge W. Two rotary motors in F-ATP synthase are elastically coupled by a flexible rotor and a stiff stator stalk. Proc Natl Acad Sci U S A. 2011 Feb 22.
  2. Francis SM, Chakrabarti S, Dick FA. A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. PLoS One. 2011 Feb 22;6(2):e16434.
  3. Seferovic MD, Chen S, Pinto DM, Gupta MB. Altered liver secretion of vascular regulatory proteins in hypoxic pregnancies stimulate angiogenesis in vitro. J Proteome Res. 2011 Feb 15.
  4. Humphrey RJ, Grieci T, Schmidt J, Gagnon R, Han V, Bütter A. Feasibility of Vesicoamniotic Shunt Insertion in an Inanimate Model: Comparison of Fetoscopic and Ultrasound-Guided Techniques. Fetal Diagn Ther. 2011 Feb 24.
  5. Yip A, Hegele RA. Lipid modification in the elderly using the combination of a statin and a cholesterol absorption inhibitor. Expert Opin Pharmacother. 2011 Mar;12(4):675-8. Epub 2011 Feb 7.
  6. Kirouac KN, Ling H. Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc Natl Acad Sci U S A. 2011 Feb 7.
  7. Kirouac KN, Suo Z, Ling H. Structural mechanism of ribonucleotide discrimination by a Y family DNA polymerase. J Mol Biol. 2011 Feb 2.
  8. Lukashova V, Szabo EZ, Jinadasa T, Mokhov A, Litchfield DW, Orlowski J. CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in Na+/H+ exchanger NHE5 promotes association with {beta}-arrestin2 and endocytosis. J Biol Chem. 2011 Feb 4.
  9. Ng WK, Rosenblatt Y, Brock GB, O'Gorman DB, Siang Gan B. Phosphodiesterase inhibitors in vascular ischemia: A case report and review of their use in ischemic conditions. Can J Plast Surg. 2010 Spring;18(1):e5-9.
  10. Bock DE, Rupar CA, Prasad C. Asymptomatic critical hypoglycemia: a dangerous presentation of Glycogen Storage Disease Type Ib in infancy. Acta Paediatr. 2011 Feb 25.
  11. Spratt DE, Shaw GS. Association of the Disordered C-terminus of CDC34 with a Catalytically-bound Ubiquitin. J Mol Biol. 2011 Feb 3.
  12. Safadi SS, Barber KR, Shaw GS. Impact of Autosomal Recessive Juvenile Parkinson's Disease Mutations on the Structure and Interactions of the Parkin Ubiquitin-like Domain. Biochemistry. 2011 Feb 24.

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Jan 2011

  1. Vassall KA, Stubbs HR, Primmer HA, Tong MS, Sullivan SM, Sobering R, Srinivasan S, Briere LA, Dunn SD, Colón W, Meiering EM. Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS. Proc Natl Acad Sci U S A. 2011 Jan 21.
  2. Grohe B, Chan BP, Sørensen ES, Lajoie G, Goldberg HA, Hunter GK. Cooperation of phosphates and carboxylates controls calcium oxalate crystallization in ultrafiltered urine. Urol Res. 2011 Jan 14.
  3. Ley SH, Hegele RA, Harris SB, Mamakeesick M, Cao H, Connelly PW, Gittelsohn J, Retnakaran R, Zinman B, Hanley AJ. HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study. BMC Med Genet. 2011 Jan 5;12(1):1.
  4. Lanktree MB, et al. (including Hegele RA) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet. 2011 Jan 7;88(1):6-18.
  5. Li AX, Suchy M, Li C, Gati JS, Meakin S, Hudson RH, Menon RS, Bartha R. In vivo detection of MRI-PARACEST agents in mouse brain tumors at 9.4 T. Magn Reson Med. 2011 Jan 19.
  6. Kaneko T, Sidhu SS, Li SS. Evolving specificity from variability for protein interaction domains. Trends Biochem Sci. 2011 Jan 10.
  7. Chowda-Reddy RV, Sun H, Chen H, Poysa V, Ling H, Gijzen M, Wang A. Mutations in the P3 protein of Soybean mosaic virus G2 isolates determine virulence on Rsv4-genotype soybean. Mol Plant Microbe Interact, 2011 Jan:24(1): 37-43.
  8. Rodenhiser DI, Andrews JD, Vandenberg TA, Chambers AF. Gene signatures of breast cancer progression and metastasis. Breast Cancer Res. 2011 Jan 24;13(1):201.
  9. Santamaria-Kisiel L, Shaw GS. Identification of regions responsible for the open conformation of S100A10 using chimaeric S100A11-S100A10 proteins. Biochem J. 2011 Jan 27;434(1):37-48.
  10. Veiseh M, Turley EA. Hyaluronan metabolism in remodeling extracellular matrix: probes for imaging and therapy of breast cancer. Integr Biol (Camb). 2011 Jan 24.

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Updated by Lynn Weir, Feb 2012.