Faculty Research
Alphabetical List/Research Details Research Areas Keyword Search
Click here for faculty looking for graduate students
* indicates those researchers who do not accept graduate students
------------------------------------------------------------------------------------------------
Research Areas
1) Genome Dynamics, Epigenetics, and Gene Expression
2) Human Genetics and Clinical Biochemistry
3) Signal Transduction and Intracellular Communication
4) Macromolecular Structure and Dynamics
5) Proteomics
6) Bioinformatics
1) Genome Dynamics, Epigenetics, and Gene Expression
DNA Replication and Repair; Transcription; Mobile DNA
The focus of the Genome Dynamics, Epigenetics, and Gene Expression group is to understand the underlying cellular mechanisms
that regulate chromosome structure and function, as well as gene expression, in normal and diseased states.
We use such
techniques as bioinformatics, proteomics, genomics, molecular biology, structural biology,
epigenetics, and genetics of model organisms.
Eric Ball. . . . . . . . . . . . . cytoskeletal proteins
Nathalie Berube. . . . . . .ATRX protein
Christopher Brandl. . . . .transcriptional regulation in eukaryotic cells
Megan Davey. . . . . . . . .DNA replication
Fred Dick. . . . . . . . . . . . retinoblastoma protein (pRB)
Gabriel DiMattia. . . . . . . growth factor signalling in ovarian cancer
David Edgell . . . . . . . . . mobile genetic elements
Gregory Gloor . . . . . . . . protein coevolution
Victor Han. . . . . . . . . . . .fetal, placental, newborn growth/development
David Haniford. . . . . . . . DNA transposition
Mellissa Mann. . . . . . . . .genomic imprinting during mammalian development
Susan Meakin. . . . . . . . .receptor tyrosine kinases in the nervous system
Geoffrey Pickering. . . . . smooth muscle cells in vascular disease
David Rodenhiser. . . . . .epigenetic control in tumourigenesis/development
Peter Rogan. . . . . . . . . .inherited genetic diseases and cancer
Caroline Schild-Poulter. .cellular response to DNA damage
Joseph Torchia. . . . . . . .eukaryotic gene regulation in oncogenesis
BACK TO TOP
2) Human Genetics and Clinical Biochemistry
Disease-Based Research; Clinical Studies
Scientists in the Human Genetics and Clinical Biochemistry group perform basic research of the molecular causes behind specific human diseases and/or clinical studies involving specific human diseases. This research integrates state-of-the-art
molecular technologies and bioinformatics with clinical work, so that basic research discoveries
can be translated into effective treatments and cures for patients.
Peter Ainsworth. . . . . . .neurofibromatosis type I
Nathalie Berube. . . . . . .ATRX protein
Vipin Bhayana*. . . . . . . cardiac biomarkers for heart attack detection
Alan Dennis*. . . . . . . . . clinical diagnostics for cancer and pregnancy
Bonnie Deroo. . . . . . . . .estrogen receptor beta in fertility and cancer; and
. . . . . . . . .role of thioredoxin interacting protein in ovary
Fred Dick. . . . . . . . . . . . retinoblastoma protein (pRB)
Gabriel DiMattia. . . . . . .growth factor signalling in ovarian cancer
Madhulika Gupta. . . . . . perinatal diseases
Victor Han. . . . . . . . . . . fetal, placental, newborn growth/development
Robert Hegele. . . . . . . .genetic basis of specific human diseases
Murray Huff. . . . . . . . . . lipoprotein metabolism and atherosclerosis
Mellissa Mann. . . . . . . ..genomic imprinting during mammalian development
Susan Meakin. . . . . . . . receptor tyrosine kinases in the nervous system
David O'Gorman. . . . . . .wound healing and Dupuytren's contracture
Geoffrey Pickering. . . . . smooth muscle cells in vascular disease
Victor Prabhakaran*. . . clinical evaluation of kidney biomarkers and assays
Jack Rip. . . . . . . . . . . . . diagnostics of metabolic diseases; glycoproteins
David Rodenhiser. . . . . epigenetic control in tumourigenesis/development
Peter Rogan. . . . . . . . . inherited genetic diseases and cancer
Anthony Rupar. . . . . . . .therapies for metachromatic leukodystrophy
Caroline Schild-Poulter. cellular response to DNA damage
Walter Siqueira. . . . . . . acquired enamel pellicle and salivary components
Victoria Siu*. . . . . . . . . .metabolic and genetic disorders
Norman Smith*. . . . . . . drug detection, measurement in biological matrices
Joseph Torchia. . . . . . . .eukaryotic gene regulation in oncogenesis
Eva Turley. . . . . . . . . . . signalling paths of cell motility and tumour invasion
Liju Yang*. . . . . . . . . . . trace element analyses of clinical specimens; . . . . . . . . . . . . clinical evaluation of kidney biomarkers and assays
BACK TO TOP
3) Signal Transduction and Intracellular Communication
Signalling Pathways
Researchers in the field of Signal Transduction and Intracellular Communication investigate the mechanisms and role of cellular signalling pathways in the regulation of fundamental biological processes. These events include cell proliferation, cell survival, differentiation, and development. This research exploits such techniques as bioinformatics, genomics, proteomics, cellular and molecular biology, structural biology, and transgenic and knockout technologies.
Eric Ball. . . . . . . . . . . . . .cytoskeletal proteins
Bonnie Deroo. . . . . . . . . estrogen receptor beta in fertility and cancer; and
. . . . . . . . . role of thioredoxin interacting protein in ovary
Fred Dick. . . . . . . . . . . . .retinoblastoma protein (pRB)
Harvey Goldberg. . . . . . .bone proteins
Murray Huff. . . . . . . . . . .lipoprotein metabolism and atherosclerosis
Shawn Li. . . . . . . . . . . . .structure, function, connectivity of cellular proteins
David Litchfield. . . . . . . . signalling events in cell proliferation and survival
Susan Meakin. . . . . . . . .receptor tyrosine kinases in the nervous system
David O'Gorman. . . . . . . wound healing and Dupuytren's contracture
Geoffrey Pickering. . . . . .smooth muscle cells in vascular disease
Gary Shaw . . . . . . . . . . .calcium signalling proteins; protein degradation
Eva Turley. . . . . . . . . . . .signalling paths of cell motility and tumour invasion
BACK TO TOP
4) Macromolecular Structure and Dynamics
Protein Biochemistry; Structural Biology
Members of the Macromolecular Structure and Dynamics Group study the role that specific proteins and protein systems play in certain diseases, with a focus on understanding protein
function at the atomic and molecular levels. We frequently use biophysical techniques and conventional molecular biology to determine the 3-D structure, dynamics, and interactions of biomolecules. Methods include NMR spectroscopy, crystallography, proteomics, and mass spectrometry.
Eric Ball. . . . . . . . . . . . . . cytoskeletal proteins
James Choy. . . . . . . . . . .intrinsically disordered proteins
Stanley Dunn . . . . . . . . . ATP synthase
Harvey Goldberg. . . . . . .bone proteins
Robert Hudson. . . . . . . . bioorganic chemistry of nucleic acids and peptides
Graeme Hunter. . . . . . . . protein regulators of biomineralization
Lars Konermann. . . . . . . protein folding, dynamics, function; biocomputing
Gilles Lajoie. . . . . . . . . . .mass spectrometry/proteomics: biomolecules
Shawn Li. . . . . . . . . . . . .structure, function, connectivity of cellular proteins
Hong Ling. . . . . . . . . . . . translesion DNA synthesis
David Litchfield. . . . . . . . signalling events in cell proliferation and survival
David O'Gorman. . . . . . . wound healing and Dupuytren's contracture
Gary Shaw . . . . . . . . . . . calcium signalling proteins; protein degradation
Brian Shilton. . . . . . . . . . ATP-dependent transmembrane transporters
Walter Siqueira. . . . . . . .acquired enamel pellicle and salivary components
Ken Yeung. . . . . . . . . . . .microscale protein analysis
BACK TO TOP
5) Proteomics
Biomolecular Characterization; Disease-Based Research
This group uses proteomic techniques to understand normal cellular processes and alterations in these processes in diseases such as cancer, fetal disorders, and oral diseases. Through biomolecular identification and characterization, we aim to develop prognostics, diagnostics, and therapeutics for these diseases.
Madhulika Gupta. . . . . . . perinatal diseases
Victor Han. . . . . . . . . . . . fetal, placental, newborn growth/development
Lars Konermann. . . . . . . protein folding, dynamics, function; biocomputing
Gilles Lajoie. . . . . . . . . . .mass spectrometry/proteomics: biomolecules
Shawn Li. . . . . . . . . . . . . structure, function, connectivity of cellular proteins
David Litchfield. . . . . . . . .signalling events in cell proliferation and survival
Walter Siqueira. . . . . . . . acquired enamel pellicle and salivary components
Ken Yeung. . . . . . . . . . . . microscale protein analysis
BACK TO TOP
6) Bioinformatics
Disease Prediction; Protein Coevolution; Biocomputing
We apply bioinformatic approaches to further our understanding of biological processes. In addition to computational and information technologies, we use genomics, molecular biology, and high-throughput sequencing.
James Choy. . . . . . . . . . .intrinsically disordered proteins
Stanley Dunn . . . . . . . . . ATP synthase
David Edgell . . . . . . . . . . mobile genetic elements
Gregory Gloor . . . . . . . . .protein coevolution
Lila Kari*. . . . . . . . . . . . . biocomputing and bioinformatics
Gilles Lajoie. . . . . . . . . . .mass spectrometry/proteomics: biomolecules
Shawn Li. . . . . . . . . . . . . structure, function, connectivity of cellular proteins
Peter Rogan. . . . . . . . . . .inherited genetic diseases and cancer
BACK TO TOP
Last updated by Lynn Weir, Dec 2011.
