Dr. McLachlin's 3rd year lab
Biochemistry 2280 profs
golfers

 

Biochemistry and Molecular Biology

Biochemistry 2280A

 

Students should use their Sakai gateway for course based materials.

Description and Goals

Biochemistry, the study of the molecules of life, centres on four key groups of biomolecules: Proteins, Lipids, Carbohydrates and Nucleic Acids.

Living cells can be considered as small factories where biomolecules serve as building blocks, machines, fuel and blueprints for all functions. The goals for this course are to explore the structure and function of these key biomolecules, mechanics by which the cellular machinery is supplied with energy and how the genetic material is converted to functional information.

The course also introduces a fundamental tool of molecular biology, recombinant DNA technology, as the ability to manipulate genetic material. This technology has made a profound change in how we study and utilize cell functions in Biotechnology.

Course Requisites:

Biology 1222 or 1223 (formerly Biology 022 and 023) and Chem 1050 (formerly Chemistry 020 or 023).

Lecturers:

Dr. Bonnie Deroo, Dr. Derek McLachlin
Course co-ordinator Dr. Chris Brandl

Lecture Schedule:

- 3 one hour lectures
Section 001 - MWF 2:30 - 3:30 OR
Section 002 TTF 3:30 - 4:30

Textbook:
Essential Cell Biology Third Edition - Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. Garland Publishing Inc.

Course Package:
A Course Package may be purchased at a cost of $20.00 from the Course Office MBL, Room C5. This package includes supplemental notes, topic review questions (with answers), practice exam questions (with answers) for the midterm and final, a tutorial on how to complete Assignment 3 and the Genome 3 readings for Dr. Brandl's section of lectures.

Evaluation:
There are 3 assignments worth 5% each, an October in-class test worth 7.5%, a midterm test worth 37.5% and a final exam worth 40%.

Topics:

1. The Central Dogma
2. Amino Acids
3. Protein Structure
4. Protein Function
5. Enzyme Catalysis
6. Protein Purification

7. Lipids and Biological Membranes
8. Membrane Proteins  
9. Carbohydrates
10. Biological Forms of Energy
11. Metabolism and Enzyme Reg.
12. Carbohydrate Metabolism
13. Acetyl-CoA Part 1
14. Electron Transport
15. ATP Synthesis
16. Acetyl-CoA Part 2
17. Overview: Energy Metabolism

18. Intro to DNA and RNA
19. Chromatin
20. Replication of DNA
21. DNA Repair

22. Gene Expression Overview
23. Transcription
24. RNA Processing
25. Translation
26. DNA Technology
27. Genomics
28. Molecular Biology of Cancer


Scholastic Discipline
Statement on Academic Offences
University Policy for Plagiarism
Absences from course commitments
Support Services


Revised J. Penchuk May 2012