PROTEIN STRUCTURE, ANALYSIS AND DESIGN
Biochemistry 4440A
COURSE INFORMATION
This course gives students a firm background of methods and techniques used to study protein structure, interactions, characterization and design. Techniques and applications discussed will include the theory and application of optical and NMR spectroscopies, and x-ray crystallography. Several case studies will be used to follow the logic of designing
Students should use their WebCT access for additional Course based materials.LECTURES
Monday and Wednesday 12:30-1:30 pm, Room M148, Medical Sciences Building
Course Content
Structure, Shape and Dynamics,
Protein Structure,
X-ray Crystallography of Proteins,
NMR Spectroscopy of Proteins
Analysis and Characterization,
Optical Spectroscopy,
Circular Dichroism Spectroscopy,
Fluorescence Spectroscopy
Application and Design,
Tools for Protein Design,
Protein Design Projects
ANTIREQUISITES
PREREQUISITES
Biochemistry 3381A.
INSTRUCTORS
| Course Manager | ||
| Dr. Gary Shaw | MSB 306 | 519-661-2111 x84021 |
| Instructors | ||
| Dr. Hong Ling | MSB 334 | 519-661-2111 x83557 |
| Dr. J. Choy | MSB 302 | 519-661-2111 x83161 |
Office Hours and Extra Help
Each instructor and the teaching assistant will keep fixed office hours each week to help students with questions and/or discuss assignments. These will be arranged during the first lecture. Students are encouraged to contact the TA initially and follow-up with the instructor if required. Alternatively you may email the TA or instructor to set-up an appointment. E-mailed questions to the instructors will be not be answered.EVALUATION
2 Assignments - 15% each (30%)
1 Group Project - 30%
Final Exam - 40%
Assignments There are 2 assignments in this class, each worth 15% of your final mark. You may work on your own or in groups on these assignments but everyone is expected to hand-in their own work (see Plagiarism, below). You will receive each assignment on the first day of each section and will have two weeks from the last lecture of that section to hand the assignment in. There will be 1 Group Project in this class, worth a total of 30% of your final grade. This project will consist of a 1 page initial outline (due in late October), a final write-up and a presentation. You will be placed in groups for this project. Content from the presentations will be eligible for the final exam.
Assignments must be handed-in on or before the due date and time. There will be no extensions under any circumstances. A late assignment will receive a mark of zero (0, nil, nada).
If you have academic conflicts with the midterm test dates, inform Melita Hayes in the Biochemistry Office (Room M342, Medical Sciences Building) by email or in writing as early as possible. Written requests for alternate test times will be considered up to one week before the scheduled test. If you have a non-academic conflict with the midterm test dates, consult the Dean's office to determine if accomodation is warranted.
INSTRUCTIONAL INFORMATION
No textbook required.
Scholastic Discipline
Statement on Academic Offences
University Policy for Plagiarism
Absences from course commitments
Support Services
Revised July 25, 2011 by Melita Hayes
