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Department of Biochemistry
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(photo: introductory image for the site)
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Related Macromolecular Structure Labs in the Biochemistry Department

  • Dr. Brian Shilton
  • Dr. Hong Ling
  • Dr. Stanley Dunn
  • Dr. Eric Ball
  • Dr. James Choy
  • Dr. Gary Shaw

 

CONTACT INFORMATION

Facility Director

Dr. Brian Shilton
bshilton@uwo.ca
(519)661-4124





Facility Co-Director

Dr. Hong Ling
hling4@uwo.ca
(519)661-3557




Facility Manager

Lee-Ann Briere
lbriere2@uwo.ca
(519)661-2111 ext 85296

 

 

 

Also from this web page:

About

The Macromolecular Crystallography Facility (MCF) is part of the Biochemistry Department at the University of Western Ontario. We are conveniently located in Room 333 of the Medical Sciences building.

The Big Debate

X-rays vs NMR?


Not unlike the great debate of "Macs versus PCs," there is controversy surrounding the age old question of "Which is better: X-rays or NMR?"

These days, most scientists will agree that both techniques can yield great results, however each approach has their own set of pros and cons.

  • "NMR versus synchrotron radiation." -Triendl R. Nature. 2001; 410:724.
  • "Comparison of protein structures determined by NMR in solution and by X-ray diffraction in single crystals." -Billeter, M. Q Rev Biophys. 1992 Aug;25(3):325-77.
  • "NMR structure determination in solution: a critique and comparison with X-ray crystallography." -Wagner G, et al. Annu Rev Biophys Biomol Struct. 1992;21:167-98
  • "Crystallography, NMR and virtual screening: integrated tools for drug discovery." -Muchmore SW and Hajduk PJ. Curr Opin Drug Discov Devel. 2003 Jul;6(4):544-9
  • "X-ray crystallography and NMR reveal complementary views of structure and dynamics." -Brunger AT. Nat Struct Biol. 1997 Oct;4 Suppl:862-5
  • "NMR and crystallography--complementary approaches to structure determination." -MacArther MW., et al. Trends Biotechnol. 1994 May;12(5):149-53.

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    Medical Sciences Bldg Rm 333, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    • Tel: (519) 661-2111 ext 85296 • Fax:(519) 661-3175

    Updated June, 2011 by L. Briere